| DC11375 |
KRIBB3
Featured
|
KRIBB3 is an Hsp27 and microtubule inhibitor that inhibits migration and invasion of MDA-MB-231 cells in vitro in an Hsp27-dependent manner. |
|
| DC12186 |
KRN2 bromide |
KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. |
|
| DC10454 |
KRN633
Featured
|
KRN633 is a potent and selective VEGFR inhibitor. which inhibits tyrosine phosphorylation of VEGFR-2 (IC50 = 1.16 nmol/L) in human umbilical vein endothelial cells. |
|
| DC9256 |
KS176
Featured
|
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1. |
|
| DC22806 |
KS-99 |
KS-99 (KS99) is a novel dual inhibitor of BTK and tubulin polymerization. |
|
| DC22779 |
KSC-34 |
KSC-34 (PDIA1 inhibitor KSC-34) is a potent, selective protein disulfide isomerase A1 (PDIA1) inhibitor, 30-fold selectivity for the A-site over the A' site. |
|
| DC21205 |
KT-109
Featured
|
KT-109 is a potent, selective inhibitor of DAGLβ with IC50 of 42 nM, displays about 60-fold selectivity over DAGLα. |
|
| DC21206 |
KT-172 |
KT-172 is a potent, selective inhibitor of DAGLβ with IC50 of 60 nM. |
|
| DC21311 |
KT-195 |
KT-195 is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM. |
|
| DC21207 |
KT-5720 |
KT-5720 is a highly specific PKA (cAMP-dependent protein kinase) inhibitor with Ki of 60 nM displays little to no activity for MLCK, cGPK, and PKC (Ki>2 uM). |
|
| DC23732 |
KT-5823
Featured
|
KT-5823 is a potent, highly specific PKG (cGMP-dependent protein kinase) inhibitor with Ki of 0.234 uM, displays little to no activity for MLCK, cAPK, and PKC. |
|
| DC3113 |
KU-0060648
Featured
|
KU 0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. |
|
| DC3101 |
Ku-0063794 |
KU-0063794 is a potent and highly specific mTOR inhibitor for both mTORC1 and mTORC2 with IC50 ~10 nM. |
|
| DC7447 |
KU14R |
KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines. |
|
| DC1067 |
KU-55933
Featured
|
KU-55933 is a potent and specific ATM inhibitor with IC50 and Ki of 13 nM and 2.2 nM, respectively. |
|
| DC7448 |
KU-60019
Featured
|
KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM. |
|
| DC21208 |
KuWal151 |
KuWal151 is a potent, selective cdc2-like kinase (CLK) inhibitor with IC50 of 88/510/28 nM for CLK1/2/4, respectively. |
|
| DC8522 |
KW-2449
Featured
|
KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. |
|
| DC9860 |
KW-2449 Hydrochloride
Featured
|
KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. |
|
| DC7449 |
KW-2478
Featured
|
KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1/2 |
|
| DC7582 |
KX1-004
Featured
|
KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL. |
|
| DC21211 |
KX2-361 |
KX2-361 (KX 02) is a potent, dual Src signaling/tubulin polymerization inhibitor that are under clinical evaluation.. |
|
| DC8023 |
KX2-391
Featured
|
KX2-391, the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. |
|
| DC21212 |
KY-02061 |
KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay. |
|
| DC1032 |
KY02111
Featured
|
KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting WNT signaling. |
|
| DC21213 |
KY-02327 |
KY-02327 is an orally active, small molecule inhibitor of the Dishevelled (Dvl)-CXXC5 interaction with IC50 of 3.1 uM, a metabolically stabilized KY-02061 analog. |
|
| DC21214 |
KY-04045 |
KY-04045 is a novel PAK4 inhibitor with IC50 of 8.7 uM, a basic building block in designing novel imidazo[4,5-b]pyridine-based PAK4 inhibitors.. |
|
| DC22132 |
KY-05009
Featured
|
KY-05009 (KY05009) is a potent, ATP-competitive inhibitor of Traf2- and Nck-interacting kinase (TNIK) with Ki of 100 nM. |
|
| DC10556 |
KY1220
Featured
|
KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells. |
|
| DC9880 |
KYA1797K
Featured
|
KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay). |
|
