DC9318 |
Piboserod
Featured
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Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.
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DC10728 |
Pibrentasvir(ABT-530)
Featured
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Pibrentasvir is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50s ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6. |
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DC23700 |
Piclamilast |
Piclamilast (RP-73401) is a potent and highly selective PDE4 inhibitor with IC50 of 1.2 nM. |
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DC21511 |
Pico145 |
Pico145 is a highly potent, subtype-selective TRPC1/4/5 channels inhibitor with potency ranged from 9 to 1300 pM, depending on the TRPC1/4/5 subtype and activation mechanism. |
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DC7949 |
Picoxystrobin |
Picoxystrobin is an methoxyacrylate strobilurin fungicide designed for the control of wide range of cereal diseases. |
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DC8426 |
Picropodophyllin (PPP)
Featured
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Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM. |
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DCAPI1426 |
Pidotimod
Featured
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Pidotimod is a synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses. This compound has been shown to induce dendritic cell maturation and up-regulate the expression of HLA-DR and co-stimulatory molecu |
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DC9505 |
Pifithrin-α (hydrobromide)
Featured
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Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
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DC8144 |
Pifithrin-β (hydrobromide)
Featured
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Pifithrin-β HBr (Cyclic Pifithrin-α HBr) is a potent p53 inhibitor with IC50 of 23 uM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1. |
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DC7233 |
Pifithrin-u
Featured
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Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. |
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DC9661 |
PIK-293
Featured
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PIK-293 is a PI3K inhibitor, mostly for PI3Kδ with IC50 of 0.24 μM, 500-, 100- and 50-fold less potent to PI3Kα/β/γ, respectively. |
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DC7234 |
PIK-294
Featured
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PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively. |
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DC7235 |
PIK-75
Featured
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PIK-75 is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM. |
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DC1096 |
PIK90
Featured
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PIK-90 is a potent and cell permeable inhibitor of p110α, p110β, p110γ and p110δ with IC50 of 11 nM, 350 nM, 18 nM and 58 nM, respectively. |
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DC8254 |
PIK-93
Featured
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PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM. |
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DC9747 |
PIK-III
Featured
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PIK-III, which is a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. |
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DC8184 |
Pilaralisib(XL-147; SAR245408)
Featured
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Pilaralisib (SAR245408; XL147) is selective oral pan-PI3K inhibitor. |
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DCAPI1588 |
Pilsicainide hydrochloride |
Pilsicainide hydrochloride is a selective Na+ channel blocker (IC30 values are 9 and 60 μM for inward Na+ and Ca2+ currents respectively). Shows antiarrhythmic effects in vivo. Orally active. |
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DC21938 |
Pim inhibitor 28 |
Pim inhibitor 28 is a potent, selective inhibitor of Pim1/2 with IC50 of 0.05 nM for both, demonstrates on-target Pim activity in an in vivo pharmacodynamic assay with significant inhibition of BAD phosphorylation in KMS-12-BM multiple myeloma tumors.. |
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DC9593 |
Pim1/AKK1-IN-1
Featured
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PIM/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively; also inhibits MPSK1 and TNIK. |
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DC10047 |
PIM-447 dihydrochloride
Featured
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PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase. |
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DC8795 |
Pimavanserin(ACP-103)
Featured
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Pimavanserin(ACP-103) is a potent and selective 5-HT2A receptor inverse agonist with mean pIC50 of with 8.7 in the cell-based functional assay. |
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DC8243 |
Pimecrolimus
Featured
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Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12. |
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DC8661 |
Pimelic Diphenylamide 106(TC-H 106)
Featured
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Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs. |
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DC23557 |
Pim-IN-22m |
Pim-IN-22m is a potent, selective Pim1/Pim2 inhibitor with IC50 of 24/95 pM respectively. |
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DC7236 |
Pimobendan
Featured
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Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. |
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DC9815 |
Pimodivir(VX-787)
Featured
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Pimodivir(VX-787) is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. |
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DC20505 |
Pimozide
Featured
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Pimozide is an antipsychotic agent that acts as an antagonist of the D2, D3, and D4 receptors and the 5-HT7 receptor, also is an inhbitor of STAT5. |
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DC12584 |
API-1 |
Pin1 inhibitor API-1 (API-1) is a potent, specific inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) and inhibits Pin1 cis-trans isomerizing activity with IC50 of 72.3 nM, displays remarkable selectivity over other peptidyl-prolyl |
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DC21939 |
PIN1 inhibitor VS10 |
PIN1 inhibitor VS10 is a novel potent small molecule inhibitor of PIN1 (peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1), inhibits human PIN1 isomerization with IC50 of 13.4 uM, displays >2-fold more potency than ATRA. |
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