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HuR inhibitor KH-3

  Cat. No.:  DC70499   Featured
Chemical Structure
1215115-03-9
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More than 5000 active chemicals with high quality for research!
Field of application
HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.KH-3 potently inhibits breast cancer cell growth in vitro and in vivo.KH-3 inhibits breast cancer cell invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.KH-3 suppresses breast cancer cell invasion by disrupting HuR-FOXQ1 mRNA interaction.Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1215115-03-9
Chemical Name: KH-3
Synonyms: KH-3;(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide
SMILES: C(NO)(=O)/C=C/C1SC2=CC=C(NS(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)C=C2C=1
Formula: C21H22N2O4S2
M.Wt: 430.54
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC70499 HuR inhibitor KH-3 HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.KH-3 potently inhibits breast cancer cell growth in vitro and in vivo.KH-3 inhibits breast cancer cell invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.KH-3 suppresses breast cancer cell invasion by disrupting HuR-FOXQ1 mRNA interaction.Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model.
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