HuR inhibitor KH-3
Cat. No.: DC70499
Chemical Structure
1215115-03-9
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Field of application
HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.KH-3 potently inhibits breast cancer cell growth in vitro and in vivo.KH-3 inhibits breast cancer cell invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.KH-3 suppresses breast cancer cell invasion by disrupting HuR-FOXQ1 mRNA interaction.Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model.
Cas No.: |
1215115-03-9 |
Chemical Name: |
HuR inhibitor KH-3 |
Formula: |
C21H22N2O4S2 |
M.Wt: |
430.537 |
Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
MSDS
COA
LOT NO. |
DOWNLOAD |
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2018-0101 |
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