HuR inhibitor KH-3|CAS 1215115-03-9|DC Chemicals

Cas No.:	1215115-03-9
Chemical Name:	KH-3
Synonyms:	KH-3;(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide
SMILES:	C(NO)(=O)/C=C/C1SC2=CC=C(NS(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)C=C2C=1
Formula:	C₂₁H₂₂N₂O₄S₂
M.Wt:	430.54
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC70499	HuR inhibitor KH-3	HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.KH-3 potently inhibits breast cancer cell growth in vitro and in vivo.KH-3 inhibits breast cancer cell invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.KH-3 suppresses breast cancer cell invasion by disrupting HuR-FOXQ1 mRNA interaction.Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model.