| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC5163 | A-674563 Featured | A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively. |
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| DC20612 | A-68930 hydrochloride | A-68930 is a potent, specific, orally bioavailable agonist of the D1 Dopamine receptor with EC50 of 2.5 nM. |
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| DC7351 | A-740003 | A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). |
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| DC7045 | A-769662 Featured | A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, little effect on GPPase/FBPase activity. |
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| DC11372 | A-779 Featured | A-779 is a peptide antagonist of the Mas receptor, also known as the angiotensin (1-7) (Ang (1-7)) receptor (IC50 = 0.3 nM in a radioligand binding assay). |
|
| DC7785 | A-790742 | A-790742 is a potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor, with 50% effective concentrations ranging from 2 to 7 nM against wild-type HIV-1. |
|
| DC2061 | A-803467 Featured | A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM. |
|
| DC9954 | A 804598 Featured | A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively. |
|
| DC7286 | A83-01 Featured | A83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). |
|
| DC20614 | A-832234 | A-832234 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 19 nM.. |
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| DC23183 | A-836339 | A-836339 (A836339) is a potent and selective cannabinoid CB2 receptor agonist with Ki of 0.64 and 0.76 nM for human and rat CB2 receptors, displays 425- and 189-fold selectivity over CB1 receptor, respectively. |
|
| DC9516 | A-867744 | A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. |
|
| DC11304 | A939572 Featured | A939572 is a potent, and orally bioavailable SCD1 inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively. |
|
| DC22721 | A-943931 dihydrochloride | A-943931 dihydrochloride is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively. |
|
| DC22720 | A-943931 | A-943931 is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively. |
|
| DC7046 | A-966492 Featured | A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. |
|
| DC20616 | AA 41612 Featured | AA 41612 is a potent, synthetic melanopsin antagonist with IC50 of 15.8 nM, attenuates melanopsin photocurrent in a dose-dependent manner. |
|
| DC23202 | JNJ-16259685 | aA highly potent, selective, non-competitive and centrally active mGluR1 antagonist with Ki of 0.34 nM. |
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| DC23277 | AA-115 Featured | AA-115 (APG 115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM. |
|
| DC21979 | ATF6 agonist compound A147 Featured | ATF6 agonist compound A147 is a specific, small molecule agonist of transcription factor ATF6, activates ATF6 and influences differentiation of stem cells.147 has broad antiviral activity against multiple DENV strains and serotypes and that the compound i |
|
| DC10165 | AA26-9 Featured | AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. |
|
| DC20961 | AA-861 | AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM. |
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| DC26090 | AAD777 | AAD777 (NVP-AAD777. |
|
| DC10922 | AAE871 | AAE871 (AAE-871) is a potent type I kinase inhibitor of FLT3 with IC50 of 34 nM, potently inhibits proliferation of FLT3-ITD- and D835Y-expressing cells (IC50<10 nM) through selective inhibition of FLT3 kinase activity.. |
|
| DC20618 | AAI-101 Featured | AAI-101 is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases. |
|
| DC12566 | AAK1 inhibitor 1 | AAK1 inhibitor 1 (SGC-AAK1-1) is a potent, selective inhibitor of AAK1 and BMP2K/BIKE ((BMP-2 inducible kinase)) that potently targets the ATP-binding site (AAK1 Ki =9.1 nM, BIKE Ki= 17 nM). |
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| DC21862 | AAK1 inhibitor 25A | AAK1 inhibitor 25A is a potent, selective inhibitor of AAK1 and the closely related kinase BMP2K with Ki of 8 nM (AAK1). |
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| DC12400 | AAL(S) | AAL(S) is the chiral deoxy analog of the FDA approved drug FTY720, has been shown to inhibit proliferation and apoptosis in several cancer cell lines by activating protein phosphatase 2A (PP2A).. |
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| DC23864 | AAL993 Featured | AAL993 (ZK260253) is a potent, orally active VEGFR inhibitor with IC50 of 130, 23 and 18 nM for VEGFR-1, 2 and 3, respectively. |
|
| DC10797 | AB-423 Featured | AB-423 is the first-generation Hepatitis B Virus Capsid Assembly inhibitor, which was generally safe and well tolerated in Phase 1 healthy volunteer studies. |
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