| DC48042 |
Biotin-PEG7-C2-NH-Vidarabine-S-CH3 |
Biotin-PEG7-C2-NH-Vidarabine-S-CH3 is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses. |
|
| DC48050 |
ATP-PEG8-Biotin |
ATP-PEG8-Biotin is a PEG-based linker that incorporates ATP. ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. |
|
| DC48369 |
AGB1
Featured
|
AGB1 is a fast, highly selective, and potent bump-and-hole (B&H)-PROTAC degrader for BromoTag. AGB1 exhibits degradation for Ab:Brd4BD2 L387A and Ab: BromoTag-Brd2 with pDC50s of 7.8 and 7.9. AGB1 exhibits binary affinity to VHL (Kd=125 nM). AGB1 exhibits favorable pharmacokinetic profile in mice with the DC50, 6 h of ∼13 nM. |
|
| DC48423 |
Boc-NH-PEG11-OH |
Boc-NH-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48429 |
Di(N-succinimidyl) adipate |
Di(N-succinimidyl) adipate (DSAP) is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs. |
|
| DC48432 |
tert-Butyl 11-aminoundecanoate |
tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker that refers to the PEG composition. tert-Butyl 11-aminoundecanoate is applicable to the synthesis of a series of PROTACs. |
|
| DC48434 |
TD-165
Featured
|
TD165(TD 165) is a PROTAC-based cereblon (CRBN) degrader that degrads Cav1.2α with the DC50 of 20.4 nM, comprising a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. |
|
| DC48440 |
m-PEGn-NHS ester |
m-PEGn-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48458 |
L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride |
L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride is the 13C- and 15N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48504 |
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride |
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48584 |
Mal-amido-PEG3-alcohol |
Mal-amido-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48588 |
Benzyl-PEG3-amine |
Benzyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48607 |
Cbz-PEG2-bromide |
Cbz-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48615 |
Iodo-PEG7-alcohol |
Iodo-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48618 |
Amino-PEG6-acetic acid |
Amino-PEG6-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48652 |
t-Boc-N-amido-PEG2-C6-Cl |
t-Boc-N-amido-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48653 |
t-Boc-Aminooxy-PEG4-amine |
t-Boc-Aminooxy-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48673 |
Bromo-PEG5-CH2COOtBu |
Bromo-PEG5-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48677 |
Bromo-PEG7-amine |
Bromo-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48700 |
Bromo-C4-PEG4-t-butyl ester |
Bromo-C4-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48701 |
t-Boc-N-amido-PEG5-acetic acid |
BocNH-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48728 |
Br-PEG6-CH2COOtBu |
Br-PEG6-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48729 |
Triethylene glycol monododecyl ether |
Triethylene glycol monododecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48798 |
Cbz-PEG5-Br |
Cbz-PEG5-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48801 |
Bromo-PEG7-CH2COOtBu |
Bromo-PEG7-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48802 |
t-Boc-Aminooxy-PEG4-t-butyl ester |
t-Boc-Aminooxy-PEG4-t-butyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
|
| DC48839 |
Fmoc-PEG3-alcohol |
Fmoc-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48849 |
Boc-NH-PEG7-acetic acid |
Boc-NH-PEG7-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48879 |
Acid-PEG7-t-butyl ester |
Acid-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC48882 |
Bromo-PEG8-CH2COOtBu |
Bromo-PEG8-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
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