| DC47361 |
PZ703b
Featured
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PZ703b is highly potent in killing BCL-XL dependent, BCL-2 dependent, and BCL-XL/BCL-2 dual-dependent cells in an E3 ligase (VHL)-dependent fashion. |
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| DC47362 |
MS21 |
MS21, a novel degrader of AKT, selectively inhibits the growth of PI3K/PTEN pathway-mutant cancers with wild-type KRAS and BRAF. |
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| DC47363 |
PROTAC CDK9 degrader-4 |
PROTAC CDK9 degrader-4 is a highly potent and efficacious CDK9 degrader for targeting transcription regulation. |
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| DC47364 |
ZXH-4-137 |
ZXH-4-137 is a potent and selective CRBN degrader (PROTAC). |
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| DC47365 |
di-Ellipticine-RIBOTAC |
di-Ellipticine-RIBOTAC is a dual-function small molecule that reduces c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo amyotrophic lateral sclerosis (ALS ) models. |
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| DC47366 |
CFT-2718 |
CFT-2718 is a new BRD4-targeting degrader (PROTAC) with enhanced catalytic activity and in vivo properties. |
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| DC47367 |
MS83 |
MS83 is a proof-of-concept PROTAC by linking the KEAP1 ligand to a BRD4/3/2 binder. |
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| DC47368 |
ZXH-4-130 |
ZXH-4-130 is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC). |
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| DC47369 |
Propargyl-PEG2-CH2COOH |
Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC47370 |
Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) |
Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC47371 |
1-Bromo-6-chlorohexane |
1-Bromo-6-chlorohexane is a PROTAC linker can be used in the synthesis of PROTACs. |
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| DC47372 |
Bromo-C10-OBn |
Bromo-C10-OBn is a PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC47584 |
PROTAC BRD4 ligand-2 |
PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718. |
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| DC47585 |
PROTAC CDK9 ligand-1 |
PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs. |
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| DC47586 |
(R)-Pomalidomide-pyrrolidine |
(R)-Pomalidomide-pyrrolidine, a CRBN ligand, can be connected to the ligand for protein by a linker to form PROTACs. |
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| DC47587 |
cIAP1 ligand 4 |
cIAP1 ligand 4 is a ligand for E3 ligase that can be used in the synthesis of PROTACs. |
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| DC47670 |
cIAP1 Ligand-Linker Conjugates 16 |
cIAP1 Ligand-Linker Conjugates 16 is an E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs. |
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| DC47671 |
(S,R,S)-AHPC-CO-C9-acid |
(S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs. |
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| DC47672 |
Thalidomide-4-O-C10-COOH |
Thalidomide-4-O-C10-COOH is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs. |
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| DC47673 |
(S,R,S)-AHPC-Me-decanedioic acid |
(S,R,S)-AHPC-Me-decanedioic acid is an E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs. |
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| DC47674 |
2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br |
2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br is a E3 ligase ligand-linker conjugate for PROTAC. |
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| DC47675 |
Thalidomide-Piperazine-Piperidine hydrochloride |
Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
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| DC47676 |
Thalidomide-O-C6-NHBoc |
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
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| DC47878 |
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH |
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
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| DC47879 |
Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH |
Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
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| DC47885 |
TLR4-IN-C34-C2-amide-C6-OH |
TLR4-IN-C34-C2-amide-C6-OH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
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| DC47886 |
Thalidomide-Piperazine 5-fluoride
Featured
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Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
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| DC47887 |
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc |
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc can be used for the synthesis of PROTAC BET degrader. (From patent WO2017180417A1 compound s7). |
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| DC47888 |
Thalidomide-O-amido-C6-NH2 |
Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. |
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| DC47889 |
Thalidomide-5-NH2-CH2-COOH |
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). Thalidomide-5-NH2-CH2-COOH is a ligand of E3 ligase. Thalidomide-5-NH2-CH2-COOH has the potential for the treatment of one or more diseases (extracted from patent WO2021170109A1) . |
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