| DC47886 |
Thalidomide-Piperazine 5-fluoride
Featured
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Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
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| DC47887 |
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc |
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc can be used for the synthesis of PROTAC BET degrader. (From patent WO2017180417A1 compound s7). |
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| DC47888 |
Thalidomide-O-amido-C6-NH2 |
Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. |
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| DC47889 |
Thalidomide-5-NH2-CH2-COOH |
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). Thalidomide-5-NH2-CH2-COOH is a ligand of E3 ligase. Thalidomide-5-NH2-CH2-COOH has the potential for the treatment of one or more diseases (extracted from patent WO2021170109A1) . |
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| DC47900 |
SJ995973 |
SJ995973 (PROTAC) is a uniquely potent degrader of bromodomain and extra-terminal (BET) proteins. |
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| DC47962 |
Lenalidomide-C5-amido-Boc |
Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC. |
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| DC47990 |
Folate-MS432 |
Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells. |
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| DC48040 |
Biotin-PEG8-Vidarabine |
Biotin-PEG8-Vidarabine is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses. |
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| DC48041 |
Biotin-PEG7-C2-S-Vidarabine |
Biotin-PEG7-C2-S-Vidarabine is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses. |
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| DC48042 |
Biotin-PEG7-C2-NH-Vidarabine-S-CH3 |
Biotin-PEG7-C2-NH-Vidarabine-S-CH3 is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses. |
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| DC48049 |
AU-15330 |
AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity. |
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| DC48050 |
ATP-PEG8-Biotin |
ATP-PEG8-Biotin is a PEG-based linker that incorporates ATP. ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. |
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| DC48368 |
PROTAC IRAK3 degrade-1 |
PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 (IC50 = 5 nM). |
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| DC48369 |
AGB1
Featured
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AGB1 is a fast, highly selective, and potent bump-and-hole (B&H)-PROTAC degrader for BromoTag. AGB1 exhibits degradation for Ab:Brd4BD2 L387A and Ab: BromoTag-Brd2 with pDC50s of 7.8 and 7.9. AGB1 exhibits binary affinity to VHL (Kd=125 nM). AGB1 exhibits favorable pharmacokinetic profile in mice with the DC50, 6 h of ∼13 nM. |
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| DC48370 |
MS98 |
MS98 is a potent and selective PROTAC AKT degrader. MS98 depletes cellular total AKT (T-AKT) with the DC50 value of 78 nM. MS98 binds to AKT1, AKT2, and AKT3 with Kds of 4 nM, 140 nM, and 8.1 nM, respectively. |
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| DC48371 |
XY-06-007 |
XY-06-007 is a selective and potent bump-and-hole (B&H)-PROTAC BRD4BD1L94V degrader. XY-06-007 shows a DC50, 6 h of 10 nM against BRD4BD1L94V with no degradation of off-targets. XY-06-007 demonstrates suitable pharmacokinetics for in vivo studies. |
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| DC48372 |
MS170 |
MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively. |
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| DC48373 |
dTAGV-1 TFA
Featured
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dTAGV-1 TFA is a potent and selective degrader of mutant FKBP12F36V fusion proteins. dTAGV-1 TFA can induce degradation of FKBP12F36V-Nluc in vivo. |
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| DC48374 |
LCL-ER(dec) |
LCL-ER(dec) is a potent and selective oligonucleotide-type degrader via targeting transcription factor (TFs). The main target of LCL-ER(dec) is SNIPER (specific and non-genetic inhibitor of apoptosis protein [IAP]-dependent protein erasers). LCL-ER(dec) selectively degrades ERα (estrogen receptor α) via the UPS (ubiquitin-proteasome system) with an IC50 of 31.2 μM. LCL-ER(dec) is applicable to the development of other oligonucleotide-type degraders that target different TFs. |
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| DC48423 |
Boc-NH-PEG11-OH |
Boc-NH-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC48429 |
Di(N-succinimidyl) adipate |
Di(N-succinimidyl) adipate (DSAP) is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs. |
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| DC48432 |
tert-Butyl 11-aminoundecanoate |
tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker that refers to the PEG composition. tert-Butyl 11-aminoundecanoate is applicable to the synthesis of a series of PROTACs. |
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| DC48434 |
TD-165
Featured
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TD165(TD 165) is a PROTAC-based cereblon (CRBN) degrader that degrads Cav1.2α with the DC50 of 20.4 nM, comprising a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. |
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| DC48440 |
m-PEGn-NHS ester |
m-PEGn-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC48458 |
L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride |
L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride is the 13C- and 15N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC48504 |
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride |
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC48584 |
Mal-amido-PEG3-alcohol |
Mal-amido-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC48588 |
Benzyl-PEG3-amine |
Benzyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC48607 |
Cbz-PEG2-bromide |
Cbz-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC48615 |
Iodo-PEG7-alcohol |
Iodo-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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