| DC49176 |
Acid-PEG14-t-butyl ester |
Acid-PEG14-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC49178 |
HO-PEG18-OH |
HO-PEG18-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC49183 |
Biotin-PEG10-NHS ester |
Biotin-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC49184 |
t-Boc-N-amido-PEG15-Br |
t-Boc-N-amido-PEG15-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC49195 |
m-PEG18-acid |
m-PEG18-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC49196 |
Pomalidomide-C5-Dovitinib |
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia. |
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| DC49197 |
PROTAC BRD9 Degrader-2 |
PROTAC BRD9 Degrader-2 is a BRD9 bifunctional degrader for treating cancer. |
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| DC49207 |
ML 2-14 |
ML 2-14 is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. ML 2-14 can be used in the synthesis of the PROTAC. |
|
| DC49209 |
HDAC6 degrader-1 |
HDAC6 degrader-1 is a PROTAC that comprises a selective HDAC6 inhibitor Nexturastat A (Nex A) as the HDAC6 binder, a linker and a ligand for recruiting E3 ligase. HDAC6 degrader-1 induces significant degradation of HDAC6, exhibits excellent selectivity against other HDACs, and demonstrates efficient inhibition of cell proliferation. |
|
| DC49213 |
Mal-amido-PEG15-acid |
Mal-amido-PEG15-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC49231 |
SJ10542 |
SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter. |
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| DC49232 |
PROTAC BRD9 Degrader-3 |
PROTAC BRD9 Degrader-3 is a BRD9 bifunctional degrader for treating cancer. |
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| DC49245 |
PROTAC BRD9 Degrader-4 |
PROTAC BRD9 Degrader-4 is a BRD9 bifunctional degrader for treating cancer. |
|
| DC49252 |
PROTAC ER Degrader-10 |
PROTAC ER Degrader-10 is a potent PROTAC ER degrader and can be used for cancer research. PROTAC ER Degrader-10 is extracted from patent WO2021133886, example 36. |
|
| DC49260 |
C18-PEG13-acid |
C18-PEG13-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC49266 |
ZXH-4-130 TFA |
ZXH-4-130 TFA is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC). |
|
| DC49270 |
DBCO-N-bis(PEG4-NHS ester) |
DBCO-N-bis(PEG4-NHS ester) is a PEG linker which contains two PEG4-NHS ester and a DBCO group. DBCO-N-bis(PEG4-NHS ester) is useful for protein modification or labeling. |
|
| DC49309 |
PhosTAC7 |
Similar to PROTACs in their ability to induce ternary complexes, PhosTAC7 focuses on recruiting a Ser/Thr phosphatase to a phosphosubstrate to mediate its dephosphorylation. |
|
| DC49320 |
Bromo-PEG2-acetic acid |
Bromo-PEG2-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC49364 |
PROTAC Bcl-xL degrader-3 |
PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader (WO2020163823A2, compound 44). |
|
| DC49373 |
Thiol-PEG3-acetic acid |
Thiol-PEG3-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC50135 |
PROTAC EGFR degrader 2 |
PROTAC EGFR degrader 2 is a potent PROTAC EGFR degrader. PROTAC EGFR degrader 2 exhibits excellent antiproliferative activity with IC50 of 4.0 nM and good EGFR degradation activity with DC50 of 36.51 nM. PROTAC EGFR degrader 2 can be used for the synthesis of nitroreductase (NTR)-responsive PROTAC. |
|
| DC50136 |
PROTAC AR-V7 degrader-1 |
PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC50 of 0.32 µM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC50 of 0.88 µM. |
|
| DC50137 |
MI-389 |
MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase. |
|
| DC50138 |
PROTAC ERα Y537S degrader-1 |
PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 extracts from patent WO2021143822, example 12. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader. |
|
| DC50139 |
PROTAC HSP90 degrader BP3 |
PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain certain degradation effect on HSP90 protein in MCF-7 cells (DC50=0.99 µM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell. |
|
| DC50141 |
SB1-G-187 |
SB1-G-187, a PROTAC, is a multi-kinase degrader. |
|
| DC50142 |
DB-0646 |
DB-0646, a PROTAC, is a multi-kinase degrader. |
|
| DC50219 |
NJH-2-030 |
NJH-2-030 can be used as a covalent recruiter for FEM1B in targeted protein degradation applications. |
|
| DC50247 |
Cereblon inhibitor 1 |
Cereblon inhibitor 1, an isoindoline derivative, is a cereblon E3 ubiquitin ligase modulating drug. Cereblon inhibitor 1 has the potential for cancer research. |
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