| DC50141 |
SB1-G-187 |
SB1-G-187, a PROTAC, is a multi-kinase degrader. |
|
| DC50142 |
DB-0646 |
DB-0646, a PROTAC, is a multi-kinase degrader. |
|
| DC50219 |
NJH-2-030 |
NJH-2-030 can be used as a covalent recruiter for FEM1B in targeted protein degradation applications. |
|
| DC50245 |
CFT7455
Featured
|
CFT7455 is an orally active zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3) degrader. Cemsidomide is an anti-cancer agent that binds with high affinity to the cereblon E3 ligase (Kd of 0.9 nM) (WO2022032132A1; Compound 1). |
|
| DC50247 |
Cereblon inhibitor 1 |
Cereblon inhibitor 1, an isoindoline derivative, is a cereblon E3 ubiquitin ligase modulating drug. Cereblon inhibitor 1 has the potential for cancer research. |
|
| DC50269 |
DBCO-PEG6-amine TFA |
DBCO-PEG6-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC50270 |
TCO-PEG2-Sulfo-NHS ester sodium |
TCO-PEG2-Sulfo-NHS ester sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC50038 |
PROTAC SGK3 degrader-1
Featured
|
PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate). |
|
| DC50053 |
E3 Ligase Ligand-Linker Conjugates 20
Featured
|
Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. |
|
| DC50055 |
Thalidomide-NH-C6-NH2
Featured
|
Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
|
| DC50056 |
Thalidomide-PEG2-C2-NH2
Featured
|
Thalidomide-PEG2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. |
|
| DC50057 |
E3 ligase Ligand-Linker Conjugates 30
Featured
|
E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrader[1]. |
|
| DC50058 |
VH032-C3-NH2((S,R,S)-AHPC-C3-NH2)
Featured
|
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852. UNC6852 is an EED-targeted bivalent chemical degrader[1]. |
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|
| DC50059 |
(S,R,S)-AHPC-C4-NH2
Featured
|
(S,R,S)-AHPC-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC[1].
|
|
| DC50060 |
(S,R,S)-AHPC-C2-NH2 dihydrochloride
Featured
|
(S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs[1]. |
|
| DC50061 |
Pomalidomide-C2-NH2(E3 ligase Ligand 17)
Featured
|
E3 ligase Ligand 17 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. |
|
| DC50062 |
Thalidomide-NH-PEG1-C2-NH2
Featured
|
Thalidomide-NH-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
|
| DC50063 |
(S,R,S)-AHPC-C6-NH2
Featured
|
PROTAC building block. |
|
| DC50064 |
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2)
Featured
|
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC. |
|
| DC50065 |
（S,R,S)-AHPC-CO-CI-Br
Featured
|
（S,R,S)-AHPC-CO-CI-Br is a novel protac building block, |
|
| DC50066 |
（S,R,S)-AHPC-acetamido-O-C2-amine HCI
Featured
|
（S,R,S)-AHPC-acetamido-O-C2-amine HCI is a novel PROTAC building block. |
|
| DC50068 |
(S,R,S)-AHPC-Me-C10-NH2
Featured
|
(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 |
|
| DC50069 |
(S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7)
Featured
|
(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. |
|
| DC50070 |
(S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base)
Featured
|
(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs. |
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|
| DC50071 |
(S,R,S)-AHPC-PEG2-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 6)
Featured
|
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs. |
|
| DC50072 |
(S,R,S)-AHPC-PEG3-NH2 （E3 ligase Ligand-Linker Conjugates 5）
Featured
|
(S,R,S)-AHPC-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. |
|
| DC50073 |
(S,R,S)-AHPC-PEG3-NH2 hydrochloride（E3 ligase Ligand-Linker Conjugates 5）
Featured
|
(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. |
|
| DC50074 |
(S,R,S)-AHPC-Me-C1-NH2
Featured
|
(S,R,S)-AHPC-Me-C1-NH2 is a novel PROTAC Building block. |
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|
| DC50075 |
(S,R,S)-AHPC-Me-C2-NH2
Featured
|
(S,R,S)-AHPC-Me-C2-NH2 is a novel PROTAC building block. |
.png)
|
| DC50076 |
(S,R,S)-AHPC-Me-C3-NH2
Featured
|
(S,R,S)-AHPC-Me-C3-NH2 is a novel PROTAC building block. |
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|
