Cat. No. | Product name | CAS No. |
DC40887 |
Thiol-PEG-Tetrazine (MW 5kDa)
Thiol-PEG-Tetrazine (MW 5kDa) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
DC41044 |
PROTAC KRASG12C Degrader-LC-2
PROTAC KRASG12C Degrader-LC-2 is a potent and first-in-class degrader of endogenous KRAS G12C with DC50 values between 0.25 and 0.76 μM. PROTAC KRASG12C Degrader-LC-2 is composed of a covalent KRAS G12C inhibitor MRTX849, a VHL ligand and a linker. |
|
DC41045 |
Pomalidomide-PEG1-C2-COOH
Pomalidomide-PEG1-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. |
2139348-60-8 |
DC41056 |
N-(Amino-PEG2)-N-bis(PEG3-azide)
N-(Amino-PEG2)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
DC41057 |
L-Azidohomoalanine hydrochloride
L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. |
942518-29-8 |
DC41058 |
Biotin-PEG4-hydrazide TFA
Biotin-PEG4-hydrazide (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
DC41134 |
Thalidomide-5-OH
Featured
Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs. |
64567-60-8 |
DC41138 |
N-Boc-piperazine
N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1. |
57260-71-6 |
DC41140 |
Amino-PEG4-C1-Boc
Amino-PEG4-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
864680-64-8 |
DC41141 |
endo-BCN-O-PNB
endo-BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. |
1263166-91-1 |
DC42085 |
Br-C3-methyl ester
Br-C3-methyl ester is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1. |
4897-84-1 |
DC42099 |
Maleimide-C10-NHS ester
Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. |
87981-04-2 |
DC42230 |
m-PEG7-thiol
m-PEG7-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
651042-82-9 |
DC42235 |
Monoethyl itaconate
NH2-PEG1-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
1155811-37-2 |
DC42238 |
Chlorobutanol hemihydrate
Thalidomide 5-fluoride is Thalidomide-based cereblon ligand?that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. |
835616-61-0 |
DC39826 |
Homo-PROTAC cereblon degrader 1
Featured
Homo-PROTAC cereblon degrader 1, is a cereblon degrader. |
2244520-98-5 |
DC42431 |
Thalidomide-O-amido-C3-PEG3-C1-NH2
Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. |
1799711-29-7 |
DC42432 |
Thalidomide-NH-PEG8-Ts
Thalidomide-NH-PEG8-Ts is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 8-unit PEG linker used in PROTAC technology, such as IDO1 PROTAC degrader. |
2488761-07-3 |
DC42433 |
CP5V
CP5V is a PROTAC, which specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. CP5V induces mitotic inhibition and suppresses cancer cell proliferation. |
2509359-75-3 |
DC42434 |
PROTAC IDO1 Degrader-1
PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells. |
2488851-89-2 |
DC42435 |
LC-2
Featured
LC-2 is a potent and first-in-class degrader of endogenous KRAS G12C with DC50 values between 0.25 and 0.76 μM. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines. |
2502156-03-6 |
DC42462 |
Lenalidomide-I
Lenalidomide-I (Compound 72) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570. |
2207541-30-6 |