Cat. No. | Product name | CAS No. |
DC7370 |
AZ-628
Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM For c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity For Raf kinases over a panel of 150 other kinases. |
878739-06-1 |
DC5049 |
RAF265 (CHIR-265)
Featured
RAF265 (CHIR-265) is a highly selective B-Raf and VEGFR2 inhibitor with IC50 of 3-60 nM and EC50 of 30 nM, including B-Raf, C-Raf and mutant B-Raf. |
927880-90-8 |
DC9987 |
RAF709
Featured
RAF709 is a novel Raf kinase inhibitor extracted from patent WO2014151616A1, compound example 131, has an IC50 of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively. |
1628838-42-5 |
DC11216 |
RAS inhibitor Abd-7
RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signalling. |
2351843-48-4 |
DC10949 |
RasGRP3 ligand 96
Featured
RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, showed 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively. |
2229068-13-5 |
DC7808 |
Refametinib (BAY86-9766)
Featured
Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. |
923032-37-5 |
DC7489 |
RO5126766(CH5126766)
RO5126766(CH5126766) is a Raf/MEK dual kinase inhibitor. |
946128-88-7 |
DC7491 |
RWJ67657
RWJ67657 is a selective p38α and p38β inhibitor (IC50 values are 1 and 11 μM respectively) that displays no activity at p38γ, p38δ and a range of other kinases. |
215303-72-3 |
DC2097 |
SB202190
Featured
SB 202190 is a pyridinyl imidazole that inhibits the p38 pathway. |
152121-30-7 |
DC7807 |
SB 239063
Featured
SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. |
193551-21-2 |
DC1004 |
SB-203580
Featured
SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM. |
152121-47-6 |
DC7279 |
SB-590885
Featured
SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases. |
405554-55-4 |
DC7599 |
SC1(Pluripotin)
Featured
SC1(Pluripotin) is a sustainer of mES self-renewal and ERK 1 inhibitor |
839707-37-8 |
DC7283 |
SCH-772984
Featured
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
942183-80-4 |
DC8255 |
SD-06
Featured
SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po). |
271576-80-8 |
DC7285 |
FR 180204
Featured
Selective ERK inhibitor (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α (IC50 = 10 μM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα. |
865362-74-9 |
DC7946 |
SKF-86002
Featured
SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). |
72873-74-6 |
DC8239 |
SL 0101-1
SL 0101-1 is a selective inhibitor of p90 Rsk (ribosomal S6 kinase) (IC50 = 89 nM for Rsk-2). |
77307-50-7 |
DC8384 |
Sodium Tauroursodeoxycholate (TUDC)
Featured
Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis. |
35807-85-3 |
DC2098 |
Sorafenib (BAY-43-9006)
Featured
Sorafenib Tosylate (Bay 43-9006, Nexavar) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. |
475207-59-1 |
DC8791 |
Sorafenib free base (BAY-43-9006)
Featured
Sorafenib(BAY 43-9006) is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively, BAY 43-9006 suppresses both wild-type and V599E mutant BRAF activity in vitro. |
284461-73-0 |
DC11034 |
SOS1 activator 17
SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro. |
2228955-02-8 |