Cat. No. | Product name | CAS No. |
DC2095 |
SP600125
Featured
SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively. |
129-56-6 |
DC9300 |
TA-02
Featured
TA-02 induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction. Potently inhibits p38α, CK1δ and CK1ε (IC50 values are 20, 32 and 32 nM respectively). |
1784751-19-4 |
DC7307 |
TAK-632
Featured
TAK-632 is a selective pan-RAF kinase inhibitor with IC50 values of 2.4/1.4 nM for BRAF V600E/c-RAF; > 60 fold selectivity over VEGFR. |
1228591-30-7 |
DC7304 |
TAK 715
TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. |
303162-79-0 |
DC7308 |
TAK-733
Featured
TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. |
1035555-63-5 |
DC11036 |
TCASK10
TCASK10 is a potent, highly specific inhibitor of ASK1 with IC50 of 14 nM, 30-fold selectivity over ASK2 (IC50=510 nM) and no activity against MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf. |
1005775-56-3 |
DC1099 |
Trametinib
Featured
Trametinib is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively. |
871700-17-3 |
DC7243 |
U0126
Featured
U0126-EtOH(U-0126) is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD098059. |
1173097-76-1 |
DC7889 |
URMC-099
Featured
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM. |
1229582-33-5 |
DC8473 |
Vacquinol-1
Featured
Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. |
5428-80-8 |
DC7242 |
VX-11e(TCS ERK 11e)
Featured
VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase); antitumor agent. |
896720-20-0 |
DC1061 |
VX-702 (VX702)
Featured
VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM. |
745833-23-2 |
DC4173 |
VX-745
Featured
VX-745 is a potent and selective inhibitor of p38α MAPK and p38β MAPK with IC50 of 10 nM and 220 nM, respectively. |
209410-46-8 |
DC7344 |
ZCL 278
Featured
ZCL278 is a Cdc42 small molecule modulator that directly binds to Cdc42 (Kd=11.4 uM) and inhibits Cdc42-intersectin interaction. |
587841-73-4 |
DC7719 |
ZM336372
Featured
ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc. |
208260-29-1 |
DC7868 |
AS703026(Pimasertib)
Featured
AS703026(Pimasertib) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. |
1236699-92-5 |
DC10979 |
BAY-885
Featured
BAY-885 is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM. |
2307249-33-6 |
DC7958 |
JNK-IN-8
Featured
JNK-IN-8 is a potent and irreversible JNK inhibitor that inhibits the phosphorylation of c-Jun. |
1410880-22-6 |
DC7488 |
RO4987655
Featured
RO4987655(CH-4987655) is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity. |
874101-00-5 |
DC7028 |
SB242235
Featured
SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 uM. |
193746-75-7 |
DC9873 |
Selonsertib(GS-4997)
Featured
Selonsertib(GS-4997)is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. |
1448428-04-3 |
DC26136 |
MRTX849(Adagrasib)
Featured
MRTX849(Adagrasib) is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. MRTX849 covalently binds to KRAS G12C at the cysteine at residue 12, locks the protein in its inactive GDP-bou |
2326521-71-3 |