| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11090 | GR3027 Featured | GR3027 (Golexanolone) is a GABA-A receptor modulating steroid antagonist that selectively antagonizes the enhanced activation of GABAA receptors by neurosteroids such as allopregnanolone and THDOC. |
|
| DC9299 | GRA Ex-25 Featured | GRA Ex-25 is an orally active human glucagon receptor antagonist in a transgenic murine pharmacodynamic model at 10 and 30 mpk. |
|
| DC22629 | GRL-0617 Featured | GRL-0617 is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM. |
|
| DC5147 | Molibresib (I-BET-762) Featured | GSK 525762A is a potent small molecule inhibitors that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4). |
|
| DC9515 | PI3K inhibitor GS1059615 | GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. |
|
| DC7140 | GSK1070916 Featured | GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM; displays >100-fold selectivity against the closely related Aurora A-TPX2 complex(IC50=490 nM). |
|
| DC7422 | GSK1292263 Featured | GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes. |
|
| DC7141 | Omipalisib Featured | GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively. |
|
| DC8331 | GSK2256098 Featured | GSK2256098 is small molecule FAK kinase inhibitor. |
|
| DC9943 | PI3Kδ inhibitor GS2269557 | GSK-2269557 is a potent and selective PI3Kδ inhibitor over the closely related isoforms. |
|
| DC9944 | PI3Kδ inhibitor GS2292767 | GSK2292767 is a potent and selective PI3Kδ inhibitor. |
|
| DC9712 | Iinerixibat | GSK2330672 is a highly potent, nonabsorbable ASBT(apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) . |
|
| DC8767 | GSK256066 Featured | GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. |
|
| DC8491 | GSK2879552 Featured | GSK2879552 is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. |
|
| DC9738 | GSK2881078 Featured | GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness. |
|
| DC9713 | GSK2981278 Featured | GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). |
|
| DC10787 | GSK2982772 Featured | GSK2982772 is a potent and ATP competitive RIP1 inhibitor with an IC50 of 16 nM. |
|
| DC9715 | CHR5154 Featured | GSK3117391 (CHR5154) is a HDAC inhibitor. |
|
| DC10936 | GSK3179106 Featured | GSK3179106 (GSK-3179106, GSK 3179106) is a potent, selective, first-in-class and gut-restricted with IC50 of 0.4 and 11 nM in the biochemical assay and cellular assay respectively. |
|
| DC10647 | EPZ015938(pemrametostat) Featured | GSK3326595(EPZ015938) is the first-in-class protein arginine methyltransferase-5 (PRMT5) inhibitor. |
|
| DC2070 | GSK690693 Featured | GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively. |
|
| DC7812 | GSK923295 Featured | GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. |
|
| DC10233 | Guanfacine Hydrochloride | Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect. |
|
| DC7837 | GW-3965 hydrochloride Featured | GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. |
|
| DC4233 | GW501516 Featured | GW501516 is the most selective and potent PPARβ (EC50=1.1nM) agonist that has been demonstrated to be 1,000-fold more selective in comparison to existing subtypes. |
|
| DC5061 | GYKI 52466 dihydrochloride | GYKI 52466 dihydrochloride is a selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. |
|
| DC10033 | H3B-6527 Featured | H3B-6527 is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. |
|
| DCAPI1505 | Darunavir Featured | Darunavir(TMC114) is an HIV protease inhibitor,showed potent activity against COVID-19(SARS-COV-2) . |
|
| DC8768 | HMN-214 Featured | HMN-214(IVX214) is a potent PLK1 inhibitor an average IC50 of 0.12 μM. |
|
| DC12493 | HT-2157(SNAP37889) Featured | HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3). |
|
