| DC8166 |
Molidustat(BAY 85-3934)
Featured
|
Hypoxia-inducible factor prolyl hydroxylase inhibitor |
|
| DC11262 |
IACS-010759
Featured
|
IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain. |
|
| DC10174 |
Iberdomide
Featured
|
Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay. |
|
| DC10007 |
Ibiglustat(Genz-682452）
Featured
|
Ibiglustat (Genz-682452,SAR402671), is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. |
|
| DC8983 |
Ibudilast
Featured
|
Ibudilast(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor which has been marketed for treating asthma,ibudilast (MN-166) is tested to treat acute respiratory distress syndrome (ARDS) associated with Covid-19. |
|
| DC8965 |
Ibuprofen |
Ibuprofen (Motrin) is an anti-inflammatory inhibitor targeting COX-1 and COX-2, of which is used for pain relief, fever reduction and for reducing swelling. |
|
| DC7020 |
Ibutamoren mesylate
Featured
|
Ibutamoren mesylate (MK-0677) is an orally active nonpeptide growth hormone (GH) secretagogue. |
|
| DC11303 |
CT7001 hydrochloride
Featured
|
ICEC0942 is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively. |
|
| DC3130 |
ICG-001
Featured
|
ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF-responsive genes. ICG-001 binds specifically to cyclic AMP response element-binding pro |
|
| DC8111 |
Idarubicin Hydrochloride
Featured
|
Idarubicin Hcl is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor. |
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|
| DC10538 |
IDH-305
Featured
|
IDH305 is an inhibitor of the citric acid cycle enzyme isocitrate dehydrogenase [NADP] cytoplasmic (isocitrate dehydrogenase 1; IDH1) with mutations at residue R132 (IDH1(R132)), with potential antineoplastic activity. |
|
| DC10098 |
IDO-IN-1
Featured
|
IDO-IN-1 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM, shows activity in Hela cell (IC50=12 nM). |
|
| DC9014 |
Ifosfamide |
Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer. |
|
| DC8872 |
Iguratimod
Featured
|
Iguratimod is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity. |
|
| DC10205 |
Ilaprazole
Featured
|
Ilaprazole (IY-81149) is a proton pump inhibitor; inhibits H+/K+-ATPase with an IC50 of 6.0 μM. |
|
| DCAPI1055 |
Iloperidone (Fanapt) |
Iloperidone (Fanapt) |
|
| DC4181 |
Imatinib mesylate
Featured
|
Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. |
|
| DC10406 |
Imisopasem manganese |
Imisopasem manganese (M40403) is a stable non-peptidyl mimetic of manganese superoxide MnSOD. |
|
| DC10918 |
INCB053914 |
INCB053914 (INCB-053914) is a novel potent, and selective ATP-competitive, pan-PIM kinase inhibitor with IC50 of 0.24/30.0/0.12 nM for PIM1/2/3, respectively. |
|
| DC7167 |
Capmatinib(INCB28060)
Featured
|
INCB28060 is a novel orally active inhibitor (IC50=0.13 nM) of c-MET kinase. |
|
| DC9389 |
INCB3344 |
INCB3344 is a novel, potent and selective small molecule antagonist of the mouse CCR2 receptor; inhibits the binding of CCL2 to mouse monocytes with nanomolar potency (IC50 = 10 nM).
|
|
| DC7429 |
INCB 8761
Featured
|
INCB8761(PF-4136309) is a potent, Selective, and orally bioavailable CCR2 antagonist. |
|
| DC4137 |
Indiplon
Featured
|
Indiplon is a novel sedative-hypnotic recently approved for the treatment of insomnia. |
|
| DCAPI1506 |
Mitiglinide Calcium |
Inhibitor of ATP-sensitive K+ channel activity in MIN 6 cells. Has also been shown to bind sulfonylurea receptors as well. |
|
| DC7171 |
INK-128(Sapanisertib)
Featured
|
INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM; >200-fold less potent to class I PI3K isoforms. |
|
| DC7430 |
Obeticholic acid (INT-747)
Featured
|
INT-747(Obeticholic acid; 6-ECDCA) is a potent and selective FXR agonist(EC50=99 nM) endowed with anticholestatic activity. |
|
| DC11494 |
INX-08189 |
INX-08189 is a phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay. |
|
| DC7172 |
IOWH-032 |
iOWH032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays. |
|
| DC5072 |
Duvelisib (IPI-145, INK1197)
Featured
|
IPI-145 is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. |
|
| DC9829 |
IPI-549
Featured
|
IPI-549 is an orally administered immuno-oncology development candidate that selectively inhibits PI3K-gamma. |
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