| DCAPI1034 |
Alendronate (Fosamax) |
Alendronate (Fosamax) |
|
| DC12072 |
Alflutinib (AST2818 mesylate)
Featured
|
Alflutinib (AST-2818, ASK120067) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation.. |
|
| DCAPI1495 |
Aliskiren Hemifumarate
Featured
|
Aliskiren hemifumarate(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM. |
|
| DC11495 |
Allitinib
Featured
|
Allitinib (AST-1306, ALS1306)) is a novel potent, selective irreversible EGFR and HER2 inhibitor with IC50 of 0.5 and 3 nM in cell-free assays. |
|
| DC7692 |
Almorexant HCl (Act-078573)
Featured
|
Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
|
| DC10234 |
Alosetron Hydrochloride |
Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. |
|
| DC8606 |
Alvimopan monohydrate |
Alvimopan(LY 246736; ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery. |
|
| DC8605 |
Alvimopan dihydrate |
Alvimopan(LY 246736; ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery. |
|
| DC11301 |
ALZ-801
Featured
|
ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease. |
|
| DC9830 |
AM-2394
Featured
|
AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. |
|
| DC10372 |
Amcasertib(BBI503)
Featured
|
Amcasertib(BBI503) is an orally administered investigational agent designed to inhibit cancer stem cell pathways, including Nanog, by targeting stemness kinases. |
|
| DC10621 |
Amenamevir
Featured
|
Amenamevir, also known as ASP2151, is a herpes virus helicase-primase inhibitor. |
|
| DC8618 |
AMG-319
Featured
|
AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3Kδ that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits basal AKT phosphorylation, and inhibits proliferation in lymphoid tumor cells |
|
| DC11239 |
AMG-333
Featured
|
AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. |
|
| DC9366 |
AMG 900
Featured
|
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM; >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. |
|
| DC5083 |
Cinacalcet (AMG-073) HCl
Featured
|
AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism. |
|
| DC7056 |
AMG-208
Featured
|
AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM. |
|
| DC9793 |
AMG232 |
AMG232 is a potent, selective and orally bioavailable inhibitor of MDM2−p53 interaction with IC50 value of 9.1 nM in EdU cells . |
|
| DC8845 |
AMG337
Featured
|
AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays. |
|
| DC11878 |
AMG-579 |
AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM. |
|
| DC10132 |
AMG9810
Featured
|
AMG9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). |
|
| DC8923 |
AS-1413(Amonafide) |
Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
|
| DC9406 |
Ampiroxicam |
Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
|
|
| DC11076 |
Ampreloxetine |
Ampreloxetine (TD-9855) is a potent monoamine reuptake inhibitor with pIC50 of 8.0, 8.6 and 6.8 for human NET, SERT, and DAT, respectively. |
|
| DC7058 |
Amprenavir
Featured
|
Amprenavir (Agenerase) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection. |
|
| DC7324 |
Amuvatinib (MP-470)
Featured
|
Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. |
|
| DC6311 |
Pomalidomide
Featured
|
An inhibitor of LPS-induced TNFαrelease.Pomalidomide is thalidomide derivative that displays inhibition of LPS-induced TNFα release. Shows immunomodulator and anticancer effects. |
|
| DC11965 |
Lucanthone |
An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APE1) potential antineoplastic activity, also inhibits autophagy. |
|
| DC11738 |
SCYX-7158 |
An orally-active, CNS permeable benzoxaborole antiprotozoal agent. |
|
| DC7815 |
Crisaborole(AN-2728)
Featured
|
AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines. |
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