Cat. No. | Product name | CAS No. |
DC7999 |
LDC1267
Featured
LDC1267 is a highly selective TAM(Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively. |
1361030-48-9 |
DC7451 |
LDN-193189 HCl
Featured
LDN193189 HCl is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. |
1435934-00-1 |
DC8034 |
LDN193189 free base
Featured
LDN193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively. |
1062368-24-4 |
DC9837 |
Larotrectinib (LOXO-101 sulfate)
Featured
LOXO-101 is a small molecule that was designed to block the ATP binding site of the TRK family of receptors, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases. |
1223405-08-0 |
DC11448 |
LOXO 195(Selitrectinib)
Featured
LOXO-195 is a next-generation TRK kinase (TKI) inhibitor, with IC50s of 0.6±0.1 nM, <2.5 nM for TRKA and TRKC respectively. |
2097002-61-2 |
DC7019 |
LY-2874455
Featured
LY2874455 is a novel and potent FGF/FGFR inhibitor. |
1254473-64-7 |
DC7460 |
Masitinib
Featured
Masitinib is a broad coronavirus 3CL inhibitor that effectively blocks replication of SARS-CoV-2. Science 20 Jul 2021: eabg5827 DOI: 10.1126/science.abg5827 |
790299-79-5 |
DC11285 |
MAZ51
Featured
MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 µM) without blocking VEGFC-mediated stimulation of VEGFR2. |
163655-37-6 |
DC7462 |
MGCD-265
MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively; also inhibits Ron and Tie2. |
875337-44-3 |
DC8479 |
MK-2461
MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. |
917879-39-1 |
DC7200 |
Motesanib Diphosphate (AMG-706)
Featured
Motesanib (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret. |
857876-30-3 |
DC10284 |
Motesanib
Featured
Motesanib is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is appr 10-fold more selective for VEGFR than PDGFR and Ret. |
453562-69-1 |
DC10915 |
mutant EGFR inhibitor B30
Featured
mutant EGFR inhibitor B30 is a potent, selective, next-generation EGFR mutants inhibitor with IC50 of 1.1 and 7.2 nM for EGFRL858R and EGFRL858R/T790M/C797S, respectively. |
2225887-26-1 |
DC9787 |
NAMI-A
NAMI-A is a ruthenium anticancer agent and a metastasis inhibitor. |
201653-76-1 |
DC9790 |
Nazartinib(EGF816)
Featured
Nazartinib(EGF816) is a novel covalent inhibitor of mutant-selective EGFR; overcomes T790M-mediated resistance in NSCLC. |
1508250-71-2 |
DC7211 |
Neratinib (HKI-272)
Featured
Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively. |
698387-09-6 |
DC3144 |
Nilotinib
Featured
Nilotinib (AMN-107, Tasigna) is a Bcr-Abl inhibitor with IC50 less than 30 nM. |
641571-10-0 |
DC7084 |
Nintedanib (BIBF 1120)
Featured
Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. |
656247-17-5 |
DC8608 |
BIBF 1120 esylate
Featured
Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. |
656247-18-6 |
DC9945 |
NSC-12
NSC12 is a PTX3-derived anti-FGF small molecule, inhibits FGF-dependent tumor growth, angiogenesis, and metastases,acts as a small-molecule FGF trap in cancer therapy. |
102586-30-1 |
DC9754 |
NT-157
Featured
NT157 is a selective inhibitor of IRS-1/2, IC50 values at sub-micromolar doses (ranging from 0.3 to 0.8 μM) . |
1384426-12-3 |
DC8794 |
NVP-ACC-789
Featured
NVP-ACC789 is an inhibitor of VEGFR-2 (FLK-1/KDR). |
300842-64-2 |