Cat. No. | Product name | CAS No. |
DC7167 |
Capmatinib(INCB28060)
Featured
INCB28060 is a novel orally active inhibitor (IC50=0.13 nM) of c-MET kinase. |
1029712-80-8 |
DC10082 |
ISCK03
Featured
ISCK03 is a cell-permeable inhibitor of SCF-mediated c-kit activation, completely blocking phosphorylation of c-kit in human melanoma cells at a concentration between 1 and 5 µM. |
945526-43-2 |
DC10998 |
JH-VIII-157-02
JH-VIII-157-02 is a potent, orally active, CNS-permeable, second-generation inhibitor of ALK G1202R mutant with IC50 of 2 nM, also shows high potency against a variety of other frequently observed mutants (G1269A, S1206Y, F1174L and C1156Y). |
1639422-97-1 |
DC10123 |
JI-101
Featured
JI-101 is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4). |
900573-88-8 |
DC10595 |
JK-P3
Featured
JK-P3 is a VEGFR-2 inhibitor. |
942655-44-9 |
DC7438 |
JNJ-28312141
JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. |
885692-52-4 |
DC8521 |
JNJ-38158471
JNJ-38158471(KDR) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50=40nM. It also inhibits closely related tyrosine kinases, Ret (180nM) and Kit (500nM). It has no significant activity (>1 microM) against VEGFR-1 and VEGF |
951151-97-6 |
DC7177 |
JNJ 38877605
Featured
JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. |
943540-75-8 |
DC9286 |
K03861
Featured
K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. |
853299-07-7 |
DC7168 |
Ki20227
Featured
Ki-20227 is a highly selective c-Fms tyrosine kinase(CSF1R) inhibitor with IC50 value of 2 nM; 6 fold and > 100 fold selectivity over VEGFR2(IC50=12 nM) and c-Kit/PDGFR_beta_(IC50=451/217 nM), respectively. |
623142-96-1 |
DC7440 |
KI8751
Featured
Ki8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM, >40-fold selective for VEGFR2 than c-Kit, PDGFRα and FGFR-2, little activity to EGFR, HGFR and InsR. |
228559-41-9 |
DC8127 |
KRCA-0008
Featured
KRCA-0008 is a potent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50 values are 4 and 12 nM respectively). |
1472795-20-2 |
DC10454 |
KRN633
Featured
KRN633 is a potent and selective VEGFR inhibitor. which inhibits tyrosine phosphorylation of VEGFR-2 (IC50 = 1.16 nmol/L) in human umbilical vein endothelial cells. |
286370-15-8 |
DC8522 |
KW-2449
Featured
KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. |
1000669-72-6 |
DC7582 |
KX1-004
Featured
KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL. |
518058-84-9 |
DC8023 |
KX2-391
Featured
KX2-391, the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. |
897016-82-9 |
DCAPI1512 |
Lapatinib
Featured
Lapatinib |
231277-92-2 |
DC3143 |
Lapatinib ditosylate
Featured
Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. |
388082-78-8 |
DC9433 |
Lapatinib (ditosylate)
Lapatinib ditosylate(GW-572016 ditosylate) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. |
388082-77-7 |
DC10598 |
lavendustin A
Featured
Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. |
125697-92-9 |
DC11900 |
Lazertinib
Featured
Lazertinib (YH25448, GNS-1480) is a highly potent, mutant-selective, irreversible, brain-penetrant and orally active EGFR tyrosine-kinase inhibitors for both the T790M mutation and activating EGFR mutations |
1903008-80-9 |
DC9626 |
Lck Inhibitor
Lck Inhibitor is a new class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM. IC50 Value: 7 nM [1] Target: Lck in vitro: Lck Inhibitor (compound 25) exhibited good potency in the T-cell receptor-induced IL-2 secretion assay (I |
847950-09-8 |