R916562|R 916562;R-916562;R562

Cas No.:	1037798-41-6
Chemical Name:	1H-1,2,4-Triazole-3,5-diamine, N3-[4-[4-(1R,2R,4S)-bicyclo[2.2.1]hept-2-yl-1-piperazinyl]phenyl]-1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-
Synonyms:	R 916562;R-916562;R562
SMILES:	N(C1N=C(Cl)N=C2C(C)=CSC2=1)1C(N)=NC(NC2=CC=C(N3CCN([C@H]4CC5CC4CC5)CC3)C=C2)=N1
Formula:	C₂₆H₃₀ClN₉S
M.Wt:	536.099
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

R916562 (R562) is a potent, dual Axl/VEGF-R2 inhibitor with celluar IC50 of 136 nM for Axl; blocks growth of MDA-MB-231 breast carcinomas implanted subcutaneously in nu/nu mice, also shows efficacy in the Caki-1 human renal carcinoma xenograft model.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47331	AZ14145845	AZ14145845 is a highly selective type I1/2 dual Mer/Axl kinase inhibitor with in vivo efficacy.
DC10995	R916562	R916562 (R562) is a potent, dual Axl/VEGF-R2 inhibitor with celluar IC50 of 136 nM for Axl.