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BN82002

  Cat. No.:  DC10909   Featured
Chemical Structure
396073-89-5
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More than 5000 active chemicals with high quality for research!
Field of application
CDC25 Phosphatase Inhibitor I, BN82002, is a cell-permeable ortho-hydroxybenzylamino compound that has been reported to display antitumor properties.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 396073-89-5
Chemical Name: 4-(dimethylamino)-2-methoxy-6-({methyl[2-(4-nitrophenyl)ethyl]amino} methyl)phenol
Synonyms: BN82002;237SRB7UQX;CDC25 Phosphatase Inhibitor I, BN82002;BN 82002;CDC25 Phosphatase Inhibitor I;GOKYHQGRIIXMNE-UHFFFAOYSA-N;BCP29552;BN82002 HYDROCHLORIDE SALT;HSCI1_000079;Phenol, 4-(dimethylamino)-2-methoxy-6-((methyl(2-(4-nitrophenyl)ethyl)amino)methyl)-;N-(2-Hydroxy-3-methoxy-5-dimethylamino)benzyl, N′-(2-(4-nitrophenethyl)), N′′-methylamine
SMILES: O([H])C1C(=C([H])C(=C([H])C=1C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])[N+](=O)[O-])N(C([H])([H])[H])C([H])([H])[H])OC([H])([H])[H]
Formula: C19H25N3O4
M.Wt: 359.4195
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BN82002 is a synthetic inhibitor of CDC25 phophatases, with IC50s of 2.4-6.3 μM for recombinant CDC25 phosphatases.
Target: IC50: 2.4 μM (CDC25A), 3.9 μM (CDC25B2), 6.3 μM (CDC25B3), 5.4 μM (CDC25C), 4.6 μM (CDC25C-cat)[1].
In Vitro: The effect of BN82002 on cell proliferation is evaluated in vitro on several human tumor cell lines. Menadione, which has been reported to inhibit cell proliferation, is used as a control. All of the examined cell lines are sensitive to BN82002 and Menadione in a concentration-dependent manner in the low micromolar range. The most sensitive is the pancreatic cancer cell line MIA PaCa-2 with an IC50 of 7.2 μM, and the less sensitive cell line is the colon cancer HT-29 with an IC50 of 32.6 μM. The range of activity is very similar to the one observed with menadione (5-15 μM). It is also showed that 50 μM BN82002 is a concentration that fully inhibits cell proliferation, the cell cycle distribution is only modestly affected with a slight decrease in S phase and an increase in cells containing both a G1 and a G2 DNA content, suggesting that the cells treated with BN82002 are arrested at various stages of the cell cycle[1].
References: [1]. Brezak MC, et al. A novel synthetic inhibitor of CDC25 phosphatases: BN82002. Cancer Res. 2004 May 1;64(9):3320-5.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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