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CFTR Inhibitor II

  Cat. No.:  DC7039   Featured
Chemical Structure
328541-79-3
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Field of application
CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 328541-79-3
Chemical Name: Glycine, N-2-naphthalenyl-, [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
Synonyms: Glycine, N-2-naphthalenyl-, [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;N-2-Naphthalenyl-glycine 2-[(3,5-Dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;CFTR Inhibitor II;CFTR Inhibitor II, GlyH-101;GLYH 101;GlyH-101;N'-[(3,5-dibromo-4-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-2-(naphthalen-2-ylamino)acetohydrazide;N-2-Naphthalenyl-gly;N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
SMILES: O=C(N/N=C/C1=CC(Br)=C(O)C(Br)=C1O)CNC2=CC3=CC=CC=C3C=C2
Formula: C19H15N3O3Br2
M.Wt: 493.1487
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC9276 KM 11060 KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity.
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DC10753 GLPG-1837(ABBV-974) GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator.
DC7039 CFTR Inhibitor II CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells.
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