KM 11060 |cas 774549-97-2|DC Chemicals

Cas No.:	774549-97-2
Chemical Name:	7-Chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline
Synonyms:	KM 11060;7-CHLORO-4-(4-(4-CHLOROPHENYLSULFONYL)PIPERAZIN-1-YL)QUINOLINE;7-chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline;7-Chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline;7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazino}quinoline;KM-11060;Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-;KM11060;7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline;7-chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazin-1-yl)quinoline;7-chloro-4-{4-[(4-chlorobenzene)sulfonyl]piperazin-1-yl}quinoline;Oprea1_790000;GTPL4234;BCP17185
SMILES:	ClC1C([H])=C([H])C2C(C=1[H])=NC([H])=C([H])C=2N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(C1C([H])=C([H])C(=C([H])C=1[H])Cl)(=O)=O
Formula:	C₁₉H₁₇Cl₂N₃O₂S
M.Wt:	422.3282
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

KM11060 is a novel corrector of the F508del-CFTR trafficking defect.Target: CFTRin vitro: Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. KM11060 rescues F508del-CFTR trafficking in cultured cells and native epithelial tissues. KM11060 partially corrects F508del-CFTR processing and increases surface expression to 75% of that observed in cells incubated at low temperature. Up to 50% of the F508del-CFTR in cells treated with KM11060 was complex-glycosylated, indicating passage through the Golgi. KM11060 as a promising compound for further development of CF therapeutics. [1]in vivo: In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice. [2]

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC1059	Lumacaftor(vx-809，vx809)	VX-809 is a CFTR modulator with EC50 of 0.1 μM.
DC7531	VX661	VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.
DC7100	CFTRinh 172	Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating.
DC7483	PPQ-102	PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.
DC9276	KM 11060	KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity.
DC4128	Ivacaftor (VX-770)	Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
DC10753	GLPG-1837(ABBV-974)	GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator.
DC7039	CFTR Inhibitor II	CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells.