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CFTRinh 172

  Cat. No.:  DC7100   Featured
Chemical Structure
307510-92-5
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More than 5000 active chemicals with high quality for research!
Field of application
Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 307510-92-5
Chemical Name: Benzoicacid,4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-
Synonyms: CFTRinh-172
SMILES: C(O)(=O)C1=CC=C(/C=C2\SC(=S)N(C3=CC=CC(C(F)(F)F)=C3)C\2=O)C=C1
Formula: C18H10F3NO3S2
M.Wt: 409.4
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibited CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.
In Vivo: A single intraperitoneal injection of CFTR(inh)-172 (250 μg/kg) in mice reduces by more than 90% cholera toxin–induced fluid secretion in the small intestine over 6 hours. CFTR(inh)-172 is nontoxic at high concentrations in mouse models. CFTRinh-172 significantly reduces fluid secretion to that in saline control loops, whereas an inactive CFTRinh-172 analog does not inhibit fluid secretion[1].
In Vitro: Inhibition by CFTR(inh)-172 is complete in approximately 10 minutes (t1/2=4 minutes) and is reversed after ishout with t1/2 approximately 5 minutes. CFTRinh-172 is nontoxic to FRT cells after 24 hours at concentrations up to 100 μM[1]. CFTR(inh)-172 does not alter CFTR unitary conductance (8 pS), but reduces open probability by > 90% with Ki=0.6 μM. This effect is due to increased mean channel closed time without changing mean channel open time. The Ki values for inhibition of Cl- current in wild-type, G551D, and G1349D CFTR are about 0.5 μM; however, Ki is significantly reduced to 0.2 μM for vF508 CFTR[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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