| DC1059 |
Lumacaftor(vx-809，vx809)
|
VX-809 is a CFTR modulator with EC50 of 0.1 μM. |
| DC7531 |
VX661
|
VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. |
| DC7100 |
CFTRinh 172
|
Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating. |
| DC7483 |
PPQ-102
|
PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM. |
| DC9276 |
KM 11060
|
KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity. |
| DC4128 |
Ivacaftor (VX-770)
|
Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
| DC10753 |
GLPG-1837(ABBV-974)
|
GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator. |
| DC7039 |
CFTR Inhibitor II
|
CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells. |
