Roxyl-WL|

Cas No.:	667887-37-8
Chemical Name:	1,5-dibenzylbenzo[1,2-d:4,5-d']bis([1,2,3]triazole)-4,8(1H,5H)-dione
SMILES:	N(CC1=CC=CC=C1)1C2C(=O)C3=C(C(=O)C=2N=N1)N(CC1=CC=CC=C1)N=N3
Formula:	C₂₀H₁₄N₆O₂
M.Wt:	370.372
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM; displays excellent kinase spectrum selectivity with no activity out of the 337 protein kinases; effectively augmentes the proliferation of T cells and reduces the number of regulatory T cell (Tregs), significantly suppresses tumor growth and induces immune response in melanoma (B16F10) tumor-bearing mice orally.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47597	IDO-IN-14	IDO-IN-14 is an IDO inhibitor with an IC50 value of 0.6928 nM.
DC47596	IDO-IN-15	IDO-IN-15 is an IDO1 inhibitor (IC50 < 0.51 nM).
DC46155	BMT-297376	BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.
DC42338	IDO-IN-8	IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM.
DC42337	IDO-IN-6	IDO-IN-6 (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) extracted from patent WO WO2012142237A1, Compound 1486, has an IC50 of <1 μM.
DC40744	(Rac)-Indoximod	(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes.
DC28673	IDO1-IN-2	IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity.
DC28284	(S)-IDO1-IN-5	(S)-IDO1-IN-5 (Example 1B) is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL with an IC50 value less than 1.5 µΜ. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
DC28283	(Rac)-IDO1-IN-5	(Rac)-IDO1-IN-5 (Example 1) is a racemate of IDO1-IN-5. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
DC11159	Roxyl-WL	Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM.