| DC47597 |
IDO-IN-14
|
IDO-IN-14 is an IDO inhibitor with an IC50 value of 0.6928 nM. |
| DC47596 |
IDO-IN-15
|
IDO-IN-15 is an IDO1 inhibitor (IC50 < 0.51 nM). |
| DC46155 |
BMT-297376
|
BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor. |
| DC42338 |
IDO-IN-8
|
IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM. |
| DC42337 |
IDO-IN-6
|
IDO-IN-6 (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) extracted from patent WO WO2012142237A1, Compound 1486, has an IC50 of <1 μM. |
| DC40744 |
(Rac)-Indoximod
|
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes. |
| DC28673 |
IDO1-IN-2
|
IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity. |
| DC28284 |
(S)-IDO1-IN-5
|
(S)-IDO1-IN-5 (Example 1B) is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL with an IC50 value less than 1.5 µΜ. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. |
| DC28283 |
(Rac)-IDO1-IN-5
|
(Rac)-IDO1-IN-5 (Example 1) is a racemate of IDO1-IN-5. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. |
| DC11159 |
Roxyl-WL
|
Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM. |
