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BMT-297376

  Cat. No.:  DC46155  
Chemical Structure
2251031-81-7
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More than 5000 active chemicals with high quality for research!
Field of application
BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2251031-81-7
Chemical Name: BMT-297376
SMILES: FC(C1=C(OC)N=CC=C1[C@@]2([H])CC[C@@](CC2)([H])[C@@H](CC)NC(C3=CN=C(OC)C=C3)=O)F
Formula: C23H29F2N3O3
M.Wt: 433.49
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_29948_DC46155_2251031-81-7
COA
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Cat. No. Product name Field of application
DC47597 IDO-IN-14 IDO-IN-14 is an IDO inhibitor with an IC50 value of 0.6928 nM.
DC47596 IDO-IN-15 IDO-IN-15 is an IDO1 inhibitor (IC50 < 0.51 nM).
DC46155 BMT-297376 BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.
DC42338 IDO-IN-8 IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM.
DC42337 IDO-IN-6 IDO-IN-6 (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) extracted from patent WO WO2012142237A1, Compound 1486, has an IC50 of <1 μM.
DC40744 (Rac)-Indoximod (Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes.
DC28673 IDO1-IN-2 IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity.
DC28284 (S)-IDO1-IN-5 (S)-IDO1-IN-5 (Example 1B) is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL with an IC50 value less than 1.5 µΜ. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
DC28283 (Rac)-IDO1-IN-5 (Rac)-IDO1-IN-5 (Example 1) is a racemate of IDO1-IN-5. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
DC11159 Roxyl-WL Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM.
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