SIS3|cas 521984-48-5|DC Chemicals

Cas No.:	521984-48-5
SMILES:	O=C(N1CCC(C=C(OC)C(OC)=C2)=C2C1)/C=C/C3=C(C4=CC=CC=C4)N(C)C5=C3C=CC=N5
Formula:	C₂₈H₂₈ClN₃O₃
M.Wt:	489.99
Purity:	>98%

Description:

SIS3 is a potent and selective inhibitor of Smad3. a potent regulator of the human Nox4 promoter.

References:

[1]. Boudreau HE et al. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells. Br J Cancer. 2014 May 13;110(10):2569-82. [2]. Jinnin M et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607. [3]. Di Bernardini E et al. Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor β2 (TGF-β2) pathways. J Biol Chem. 2014 Feb 7;289(6):3383-93.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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