Cat. No. | Product name | CAS No. |
DC71641 |
Adrenocorticotropic hormone
Adrenocorticotropic hormone (ACTH) is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone regulates cortisol and androgen production. |
9002-60-2 |
DC72104 |
ARD-69
ARD-69 (compound 34) is a potent PROTAC androgen receptor degrader. ARD-69 induces degradation of androgen receptor (AR) protein in AR-positive prostate cancer cell lines. ARD-69 suppresses AR-regulated gene expression. |
2316837-10-0 |
DC72105 |
EPI-7170
EPI-7170, a ralaniten analogue, is a potent androgen receptor N-terminal structural domain antagonist that blocks the transcriptional activity of full-length AR (FL-AR) and AR splice variants (AR-Vs). EPI-7170 has antitumor effects against enzalutamide resistant castration-resistant prostate cancer (CRPC). |
2139288-26-7 |
DC72758 |
Gumelutamide
Gumelutamide is a tetrahydropyridopyrimidine compound, acting as an antiandrogen, antineoplastic agent. Gumelutamide is an androgen antagonist. |
1831085-48-3 |
DC72759 |
RLA-5331
RLA-5331 is an iron activator containing anti-androgen. RLA-5331 has anti-proliferative activity on metastatic castrated tolerant prostate cancer (mCRPC) cell line and can stably exist in vivo. |
|
DC73800 |
ET516
ET516 is a potent androgen receptor liquid-liquid phase separation (AR LLPS) inhibitor, specifically disrupts AR condensates, effectively suppresses AR transcriptional activity and inhibits the proliferation and tumor growth of prostate cancer cells expre |
2820120-95-2 |
DC73801 |
Faznolutamide
Faznolutamide is a potent, selective androgen receptor (AR) antagonist. |
1272719-08-0 |
DC73802 |
JJ-450
JJ-450 is a novel analogue of IMTPPE and direct and specific inhibitor of androgen receptor (AR) transcriptional activity, blocks AR recruitment to androgen-responsive elements and suppresses AR target gene expression. |
2772026-11-4 |
DC73803 |
M17-B15
M17-B15 is a potent, specific small molecule inhibitor of androgen receptor (AR) targeting the dimer interface pocket (DIP), inhibits AR transcriptional inhibition with IC50 of 0.03 uM. |
708291-86-5 |
DC73804 |
MK-0773
A potent, selective androgen receptor modulator (SARM) with binding IC50 of 6.6 nM. |
606101-58-0 |
DC73805 |
SC428
SC428 (SC-428) is a small molecule androgen receptor (AR) signaling inhibitor, directly binds to the AR N-terminal domain (NTD) and exhibits pan-AR inhibitory effect. |
1898232-70-6 |
DC73806 |
UT-105
UT-105 is a small-molecule, irreversible, selective androgen receptor (AR) degrader (SARD) and irreversible inhibitor, binds to AR N-terminal domain (NTD) and inhibits both the AR and AR splice variants (AR-SVs). |
2388536-21-6 |
DC73807 |
UT-215
UT-215 (UT215) is a small-molecule selective androgen receptor (AR) irreversible covalent antagonist, covalently and selectively bind to C406 and C327 in the AF-1 region of AR. |
2698320-28-2 |
DC74595 |
Deutenzalutamide
Deutenzalutamide (HC-1119, MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. It can be used in a treatment of advanced prostate cancer. |
1443331-82-5 |