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ABM-14

  Cat. No.:  DC42465  
Chemical Structure
1973408-76-2
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More than 5000 active chemicals with high quality for research!
Field of application
ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 to degrade AR。
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1973408-76-2
Chemical Name: ABM-14
Synonyms: ABM-14
SMILES: C1C=C(O)C=CC=1C1C=CC(N2C(C)(C(N(C3=CC(C(F)(F)F)=C(N)C=C3)C2=S)=O)C)=CC=1
Formula: C24H20F3N3O2S
M.Wt: 471.494714736938
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
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COA
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Cat. No. Product name Field of application
DC45607 JNJ-63576253 (TRC-253) JNJ-63576253 (TRC-253) is a potent and selective androgen receptor (AR) Antagonist with IC50 of 6.9 nM. JNJ-63576253 displays robust inhibition in WT and LBD-mutated, enzalutamide-resistant models of prostate cancer.
DC44798 ARV-110 ARV-110 is an orally active, specific androgen receptor (AR) PROTAC degrader. ARV-110 promotes ubiquitination and degradation of AR. ARV-110 can be used for the research of prostate cancer.
DC42525 (R)-Bicalutamide (R)-Bicalutamide is the (R)-enantiomer of Bicalutamide. (R)-Bicalutamide is an androgen receptor (AR) antagonist, with an antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer.
DC42465 ABM-14 ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 to degrade AR。
DC12102 UT-155 UT-155 is a selective androgen receptor (AR) antagonist, with a Ki of 267 nM for AR-RBD.
DC8690 ORM-15341(Ketodarolutamide) ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.
DC9347 N-desmethyl Enzalutamide N-desmethyl Enzalutamide(N-desmethyl MDV3100) is a major metabolite of Enzalutamide, Enzalutamide(MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM.
DC74595 Deutenzalutamide Deutenzalutamide (HC-1119, MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. It can be used in a treatment of advanced prostate cancer.
DC73807 UT-215 UT-215 (UT215) is a small-molecule selective androgen receptor (AR) irreversible covalent antagonist, covalently and selectively bind to C406 and C327 in the AF-1 region of AR.
DC73806 UT-105 UT-105 is a small-molecule, irreversible, selective androgen receptor (AR) degrader (SARD) and irreversible inhibitor, binds to AR N-terminal domain (NTD) and inhibits both the AR and AR splice variants (AR-SVs).
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