JNJ-63576253 (TRC-253)|CAS 2110426-27-0|DC Chemicals

Cas No.:	2110426-27-0
Chemical Name:	JNJ-63576253
Synonyms:	5-[8-Oxo-5-[6-(4-piperidinyloxy)-3-pyridinyl]-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)-2-pyridinecarbonitrile
SMILES:	C(F)(F)(C1=CC(N2C(N(C3C=CC(=NC=3)OC3CCNCC3)C3(CCC3)C2=O)=S)=CN=C1C#N)F
Formula:	C₂₃H₂₁F₃N₆O₂S
M.Wt:	502.51
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC45607	JNJ-63576253 (TRC-253)	JNJ-63576253 (TRC-253) is a potent and selective androgen receptor (AR) Antagonist with IC50 of 6.9 nM. JNJ-63576253 displays robust inhibition in WT and LBD-mutated, enzalutamide-resistant models of prostate cancer.
DC44798	ARV-110	ARV-110 is an orally active, specific androgen receptor (AR) PROTAC degrader. ARV-110 promotes ubiquitination and degradation of AR. ARV-110 can be used for the research of prostate cancer.
DC12102	UT-155	UT-155 is a selective androgen receptor (AR) antagonist, with a Ki of 267 nM for AR-RBD.
DC8690	ORM-15341(Ketodarolutamide)	ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.
DC9347	N-desmethyl Enzalutamide	N-desmethyl Enzalutamide(N-desmethyl MDV3100) is a major metabolite of Enzalutamide, Enzalutamide(MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM.