| DC44036 |
4-Methylcinnamic acid |
4-Methylcinnamic acid, a Cinnamic acid analog, can be used as a intervention catalyst for overcoming antifungal tolerance. 4-Methylcinnamic acid can improve the potency of cell wall-disrupting agents. |
|
| DC44079 |
Methyl p-coumarate |
Methyl p-coumarate (Methyl 4-hydroxycinnamate), an esterified derivative of p-Coumaric acid (pCA), is isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens. |
|
| DC44094 |
2-Ethyl-6-methylphenol |
2-Ethyl-6-methylphenol, alkylphenol, is isolated form the tumorigenic neutral subfraction of cigarette smoke condensate. 2-Ethyl-6-methylphenol exhibits insecticidal and bactericidal activities. |
|
| DC44110 |
β-Lactamase-IN-2(UUN51204;Schembl20899335)
Featured
|
β-Lactamase-IN-2 is a beta-lactamase inhibitor, extracted from patent WO 2019075084 A1, compound 1. β-Lactamase-IN-2 has anti-microbial and anti-bacterial effects. |
|
| DC44111 |
Ibezapolstat |
Ibezapolstat (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat is developed for the research of C. difficile infection(CDI). |
|
| DC44112 |
2',3'-Dideoxy-5-iodocytidine
Featured
|
2',3'-Dideoxy-5-iodocytidine is used for gene sequencing can be used as an antibiotic. 2',3'-Dideoxy-5-iodocytidine is particular effective against Mycobacterium. |
|
| DC44113 |
Ibrexafungerp citrate
Featured
|
Ibrexafungerp citrate is a triterpenoid antifungal. Similarly to echinocandins, it inhibits the synthesis of 1,3-β-d-glucan. However, it binds to a different site on the enzyme than echinocandins, resulting in limited cross-resistance. Ibrexafungerp exerts concentration-dependent fungicidal activity against Candida species and retains in vitro activity against most fluconazole-resistant strains. |
|
| DC44114 |
Pyribencarb
Featured
|
Pyribencarb is a benzylcarbamate-type fungicide, which is active against a wide range of plant pathogenic fungi. Pyribencarb is a potent Qo inhibitor of cytochrome b. Pyribencarb is especially active against Botrytis cinerea and Sclerotinia sclerotirum. |
|
| DC44115 |
1-Dodecylimidazole |
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity. |
|
| DC44116 |
HBV-IN-4 |
HBV-IN-4, a phthalazinone derivative, is a potent and orally active HBV DNA replication inhibitor with an IC50 of 14 nM. HBV-IN-4 induces the formation of genome-free capsids and has potent anti-HBV potencies. |
|
| DC44117 |
HCV-IN-31 |
HCV-IN-31 (compound 4) is a HCV inhibitor, with an EC50/EC95 of 15.7 μM for HCV replicon. |
|
| DC44118 |
Reverse transcriptase-IN-1 |
Reverse transcriptase-IN-1 (Compound 12z), a diarylbenzopyrimidine (DABP) analogue, is a potent, orally active HIV-1 nonnucleoside reverse transcriptase inhibitor. Reverse transcriptase-IN-1 has antiviral activity with EC50 values of 3.4 nM, 4.3 nM and 3.6 nM for HIV-1 IIIB, E138K and K103N mutants, respectively. Reverse transcriptase-IN-1 also has an IC50of 13.7 nM against HIV-1 reverse transcriptase enzyme. |
|
| DC44119 |
Nevirapine-D4 |
Nevirapine-D4 is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM. |
|
| DC44120 |
Melarsomine |
Melarsomine is a trivalent arsenical compound used as an adulticide. Melarsomine can be used for the reserach of canine heartworm disease and other helminth infections. |
|
| DC44121 |
Melarsomine dihydrochloride |
Melarsomine dihydrochloride is a trivalent arsenical compound used as an adulticide. Melarsomine dihydrochloride can be used for the reserach of canine heartworm disease and other helminth infections. |
|
| DC53050 |
ATI-2173
Featured
|
ATI-2173 is a novel liver-targeted molecule designed to deliver the 5′-monophosphate of clevudine for the treatment of chronic hepatitis B infection. |
|
| DC53052 |
AT-273
Featured
|
AT-273 is the nucleoside metabolite of AT-527. |
|
| DC44536 |
Neticonazole |
Neticonazole (SS717) is a selecvie inhibitor of exosome biogenesis and secretion. Neticonazole exhibits Neticonazole antifungal and antitumor activity. |
|
| DC44753 |
Dimercaprol |
Dimercaprol (Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol) is an acrolein scavenger that inhibits HIV-1 tat activity, viral production, and infectivity in vitro. |
|
| DC44754 |
Cetylpyridinium chloride monohydrate |
Cetylpyridinium chloride (CPC, Hexadecylpyridinium chloride) monohydrate is a broad-spectrum antimicrobial agent that possesses virucidal activity against susceptible and resistant strains of influenza virus by targeting and disrupting the viral envelope. |
|
| DC55000 |
Jun8-76-3A
Featured
|
Jun8-76-3A is a potent and selective noncovalent SARS-CoV-2 Mpro inhibitor with Ki of 0.07 μM. Jun8-76-3A only selectively inhibits SARS-CoV-2 and SARS-CoV Mpro, but not other viral proteases and host proteases including calpain 1, cathepsins L and K, and trypsin. |
|
| DC44803 |
Caprazamycin |
Caprazamycin is a liponucleoside antibiotic. |
|
| DC44804 |
Monascorubrin |
Monascorubrin is purified from the mycelium of Monascus purpureus. Monascorubrin has significant antibiotic activities against Bacillus subtilis and Candida pseudotropicalis. |
|
| DC44810 |
Lalistat 1 |
Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC50 of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease. |
|
| DC44811 |
Questin |
Questin is an antibacterial agent isolated from marine Aspergillus flavipes. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL. |
|
| DC44812 |
1-Heptadecanol |
1-Heptadecanol is a long-chain primary alcohol with antibacterial activity from Solena amplexicaulis leaves. |
|
| DC44813 |
1-Hydroxy-2-butanone |
1-Hydroxy-2-butanone is a natural compound isolated from Bomboo Juice with antitubercular activity. |
|
| DC44814 |
1-Naphthalenemethanol |
1-Naphthalenemethanol is a natural compound the root bark extracts of Annona senegalensis with antibacterial activity. |
|
| DC44815 |
1-Tetradecanol |
1-Tetradecanol, isolated from Myristica fragrans, is a straight-chain saturated fatty alcohol. 1-Tetradecanol possesses antibacterial and anti-inflammatory (periodontitis) activity. |
|
| DC44816 |
2-Methoxybenzaldehyde |
2-Methoxybenzaldehyde (o-Anisaldehyde), isolated from cinnamon essential oil (CEO), exists antibacterial and antifungal activity. |
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