Cat. No. | Product name | CAS No. |
DC8618 |
AMG-319
Featured
AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3Kδ that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits basal AKT phosphorylation, and inhibits proliferation in lymphoid tumor cells |
1608125-21-8 |
DC9366 |
AMG 900
Featured
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM; >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. |
945595-80-2 |
DC7056 |
AMG-208
Featured
AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM. |
1002304-34-8 |
DC9793 |
AMG232
AMG232 is a potent, selective and orally bioavailable inhibitor of MDM2−p53 interaction with IC50 value of 9.1 nM in EdU cells . |
1352066-68-2 |
DC8845 |
AMG337
Featured
AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays. |
1173699-31-4 |
DC8923 |
AS-1413(Amonafide)
Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
69408-81-7 |
DC7324 |
Amuvatinib (MP-470)
Featured
Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. |
850879-09-3 |
DC6311 |
Pomalidomide
Featured
An inhibitor of LPS-induced TNFαrelease.Pomalidomide is thalidomide derivative that displays inhibition of LPS-induced TNFα release. Shows immunomodulator and anticancer effects. |
19171-19-8 |
DC11965 |
Lucanthone
An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APE1) potential antineoplastic activity, also inhibits autophagy. |
479-50-5 |
DC1020 |
Ponatinib (AP24534)
Featured
AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively. |
943319-70-8 |
DC4101 |
Apatinib Mesylate
Featured
Apatinib (YN968D1) is an orally bioavailable, selective VEGFR2 inhibitor with IC50 of 1 nM. |
1218779-75-9 |
DC8275 |
Apilimod
Featured
Apilimod(STA 5326) is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. |
541550-19-0 |
DC6901 |
Daporinad(FK866,APO866)
Featured
APO866 effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM. |
658084-64-1 |
DC8664 |
APTO-253
APTO-253 is a novel small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Krüppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death. |
916151-99-0 |
DC9972 |
ARQ-092(Miransertib)
Featured
ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). |
1313881-70-7 |
DC10975 |
ARQ-531
Featured
ARQ-531 is a potent, reversible, orally available inhibitor of both wild type and C481S-mutant BTK kinase with IC50 of 0.85 and 0.39 nM, |
2095393-15-8 |
DC8486 |
Varlitinib(ARRY-334543)
ARRY-334543 is a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases. |
845272-21-1 |
DC7359 |
Asp-3026
Featured
ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM. |
1097917-15-1 |
DC10588 |
ASP-9521
Featured
ASP-9521 is a potent, selective and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3. |
1126084-37-4 |
DC7360 |
AST-1306
AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases. |
1050500-29-2 |
DC11163 |
AST-3424
Featured
AST-3424 (OBI-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent. |
2097713-68-1 |
DC2015 |
AT-101 (AT101)
AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members. |
866541-93-7 |