Cat. No. | Product name | CAS No. |
DC8226 |
RI-2
Featured
RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells. |
1417162-36-7 |
DC7265 |
Rigosertib
Featured
Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM; shows 30-fold greater selectivity against PLK2 and no activity to PLK3. |
1225497-78-8 |
DC8831 |
RKI-1313
Featured
RKI-1313 is the negative control for RKI-1447 which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer |
1342276-76-9 |
DC7269 |
RKI-1447
Featured
RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2. |
1342278-01-6 |
DC3116 |
RO-3306
Featured
Ro-3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D. |
872573-93-8 |
DC12353 |
Roniciclib (BAY 1000394)
Roniciclib is an orally bioavailable pan-cyclin dependent kinase (CDK) inhibitor, with IC50s of 5-25 nM for CDK1, CDK2, CDK3, CDK4, CDK7 and CDK9. |
1223498-69-8 |
DC4124 |
ROSCOVITINE(Seliciclib)
Featured
Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively. |
186692-46-6 |
DC5151 |
Rucaparib phosphate (AG-14699, PF-01367338)
Featured
Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM with binding affinity to nine PARP domains. Phase 1/2. |
459868-92-9 |
DC8464 |
Rucaparib(AG-014447)
Featured
Rucaparib inactivates PARP activity in cells with homologous recombination DNA repair pathway mutations at LC50 values ranging from 1.3-5.5 μM. |
283173-50-2 |
DC7762 |
RX-3117
Featured
RX-3117 is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. |
865838-26-2 |
DC10444 |
Sapacitabine (CYC682)
Featured
Sapacitabine is an orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity. |
151823-14-2 |
DC9792 |
SAR020106
Featured
SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L on the isolated human enzyme. |
1184843-57-9 |
DC8104 |
SAR407899 HCl
SAR407899 Hcl is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
923262-96-8 |
DC9854 |
SAR407899
Featured
SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
923359-38-0 |
DC9924 |
SB218078
Featured
SB218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). |
135897-06-2 |
DC5024 |
MK-8776 (SCH 900776)
Featured
SCH 900776 is a selective Chk1 inhibitor with IC50 of 3 nM. It shows 50-fold selectivity against Chk2. Phase 2. |
891494-63-6 |
DC8737 |
SCH900776 S-isomer
Featured
SCH900776 (S-isomer) is the S-isomer form of SCH900776, which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 |
891494-64-7 |
DC10628 |
Senexin A
Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively. |
1366002-50-7 |
DC8329 |
SLx-2119(KD-025,Belumosudil )
Featured
SLx-2119(KD-025) is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM) |
911417-87-3 |
DC5905 |
SN-38(NK-012)
Featured
SN-38(NK-012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
86639-52-3 |
DC7297 |
SNS-032(BMS-387032)
Featured
SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). |
345627-80-7 |
DC7246 |
SR3677
Featured
SR-3677 is a new potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays; IC50 for ROCK-I is 56 ± 12 nM. |
1072959-67-1 |