Cas No.: | 455264-31-0 |
Synonyms: | CDP-323;CDP 323;CDP323 |
SMILES: | O=C1C(Br)=C(C12CCCCC2)N[C@H](C(O)=O)CC3=CC=C(NC4=NC=CC5=CC=NC=C45)C=C3 |
Formula: | C26H25BrN4O3 |
M.Wt: | 521.4057 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | Zaurategrast(CDP-323) is an oral α4-integrin inhibitor. CDP323 significantly decreased the capacity of lymphocytes to bind vascular adhesion molecule-1 (VCAM-1) and the expression of α4-integrin on VCAM-1-binding cells.CDP323 at daily doses of 1000 or 2000 mg induced significant increases in total lymphocyte count and suppressed VCAM-1 binding by reducing unbound very late antigen-4 expression on lymphocytes. |