MP-HJ-1b

  Cat. No.:  DC11241  
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
MP-HJ-1b is a novel potent inhibitor of microtubule and tumor cell growth, binds the colchicine pocket at the intra-dimer interface, depolymerizes microtubules and affects spindle formation.
Cas No.:
Chemical Name: N-(2-(benzofuran-2-yl)benzyl)-4H-pyrrolo[2,3-d]thiazole-5-carboxamide
SMILES: S1C2C=C(C(NCC3=CC=CC=C3C3=CC4=CC=CC=C4O3)=O)NC=2N=C1
Formula: C21H15N3O2S
M.Wt: 373.43
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: MP-HJ-1b is a novel potent inhibitor of microtubule and tumor cell growth, binds the colchicine pocket at the intra-dimer interface, depolymerizes microtubules and affects spindle formation; shows activities against a panel of more than 1000 human cancer cell lines with a wide variety of tissue origins, also induces the spike-like conformation of microtubules in vitro and in vivo, which is different from typical microtubule modulators; exhibits an interesting property of general cytotoxicity instead of Ras-mutant-specific killing (A549 KRAS-G12S, IC50=0.04 uM); MPHJ-1b displayed favorable pharmacological properties for overcoming tumor MDR both in vitro and in vivo.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC47571 Dolastatinol Dolastatinol is a synthetic analog of dolastatin 10 and low nanomolar inhibitor of tubulin polymerization.
DC47570 Vinflunine Tartrate Vinflunine Tartrat is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.
DC47197 Violanone Violanone, an isoflavanone compound, can inhibit tubulin polymerization. Violanone also exhibits larvicidal activity against A. aegypti.
DC47161 Amiprofos methyl Amiprofos methyl (BAY-NTN 6867) is a phosphoric amide herbicide. Amiprofos methyl is a specific and potent antimicrotubule agent. Amiprofos methyl directly poisons microtubule dynamics in plant cells.
DC47133 Fmoc-MMAE Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Fmoc-MMAE can be used in the synthesis of ADC.
DC46357 Davunetide Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity.
DC46239 AcLys-PABC-VC-Aur0101 AcLys-PABC-VC-Aur0101 is a drug-linker conjugate for ADC (anti-CXCR4 ADC) with potent antitumor activity by using Aur0101 (an auristatin microtubule inhibitor), linked via the cleavable linker AcLys-PABC-VC.
DC46217 OSu-Glu-VC-PAB-MMAD OSu-Glu-VC-PAB-MMAD is a drug-linker conjugate for ADC with potent antitumor activity by using MMAD (a potent tubulin inhibitor), linked via the cleavable ADC linker OSu-Glu-VC-PAB.
DC46216 MC-VC-PAB-MMAD MC-VC-PAB-MMAD is a drug-linker conjugate for ADC with potent antitumor activity by using MMAD (a potent tubulin inhibitor), linked via the cleavable ADC linker MC-VC-PAB.
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