| DC20659 |
(2E,4E)-5-((1S,2S,4aR,6R,7S,8S,8aS)-7-hydroxy-2,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)-2-methyl-N-(pyridin-3-yl-methyl)penta-2,4-dienamide
Featured
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A small-molecule compound that disrupts the Golgi apparatus by inhibiting the activation of ADP-ribosylation factor 1 (ARF1). |
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| DC20558 |
STOML3 inhibitor OB-1
Featured
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OB-1 is a small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo; effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin; reversibly reduces the sensitiv |
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| DC22799 |
ML-162
Featured
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A small-molecule probe that selectively kills cells induced to express mutant RAS. |
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| DC22800 |
ML-210
Featured
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A small-molecule probe that selectively kills cells induced to express mutant RAS. |
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| DC11638 |
BCI(NSC 150117)
Featured
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BCI is A small-molecule, allosteric inhibitor of DUSP6 (dual-specificity phosphatase 6) with IC50 of 12.3 uM; also inhibits human DUSP1 with IC50 of 11.5 uM; suppresses the ERK-induced activation of Dusp6 and regulates heart size in zebrafish. |
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| DC22392 |
BRD-4592
Featured
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BRD4592 is a small-molecule allosteric inhibitor that targets the tryptophan synthase (TrpAB) of Mycobacterium tuberculosis. TrpAB is a bifunctional enzyme composed of α and β subunits, which catalyzes the final steps of tryptophan biosynthesis. BRD4592 binds at the interface of the α and β subunits, disrupting the enzyme's function. |
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| DC26093 |
PH-064
Featured
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A sodium channel inhibitor.. |
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| DC24093 |
PF-915275
Featured
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PF-915275 is a potent and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) (Ki ＜ 1 nM) with good preclinical pharmacokinetic properties.IC50 value: ＜ 1 nM (Ki)[2]Target: 11βHSD1in vitro: PF-915275 maintains potency in our cellular assay against human 11βHSD1 (HEK293, EC50 = 5 nM) and is selective against human 11βHSD2 (HEK293, 1.5% inhibition 10 μM). PF-915275 displays only weak affinity for the rodent choline transporter (Ki = 9.6 μM) and the hamster melatonin MT3 receptor (Ki = 9.6 μM) in the Cerep Bioprint screening panel. PF-915275 has good in vitro pharmacokinetic properties. In particular, PF-915275 is categorized as a low clearance compound (liver microsome assays) with high permeability (Caco2 assay). [2]in vivo: As a prelude to in vivo studies with PF-915275, the rat pharmacokinetic properties of this compound were determined. PF-915275 has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. [2] |
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| DC23022 |
PDZ1i
Featured
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A specific inhibitor of MDA-9/Syntenin activity that inhibits MDA-9/Syntenin binding to EGFRvIII. |
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| DC23589 |
CGP 37157
Featured
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A specific inhibitor of mitochondrial Na(+)-Ca(2+) exchanger (mNCE) with IC50 of 1.5 uM in INS-1 cells. |
|
| DC22669 |
ONO-1301
Featured
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A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase. |
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| DC24191 |
Cyclophosphamide hydrate
Featured
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A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. |
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| DC23906 |
Butenafine hydrochloride
Featured
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A synthetic benzylamine antifungal that inhibits the synthesis of ergosterol by inhibiting squalene epoxidase. |
|
| DC23209 |
HO-3867
Featured
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A synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. |
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| DC23965 |
Clopidogrel thiolactone
Featured
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A thienopyridine-class antiplatelet agent that works by irreversibly inhibiting P2Y12 receptor on platelets. |
|
| DC7517 |
THIACETAZONE
Featured
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A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the I |
|
| DC22457 |
NAPQI
Featured
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A toxic byproduct, iminoquinone metabolite of acetaminophen that covalently binds to the active site of MIF. |
|
| DC24092 |
Posaconazole hydrate
Featured
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A triazole antifungal agent that blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors, more potent at inhibiting 14α-demethylase than itraconazole.. |
|
| DC8197 |
Tyrosine kinase inhibitor
Featured
|
A Tyrosine kinase inhibitor. |
|
| DC11578 |
VHL Ligand 3
Featured
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A VHL ligand for PROTAC.. |
|
| DC23233 |
AH 6809
Featured
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A xanthone derivative that fuctions as an EP and DP receptor antagonist. |
|
| DC9768 |
A1155463
Featured
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A-1155463 is a highly potent and selective BCL-XL inhibitor. |
|
| DC8475 |
A-1210477
Featured
|
A-1210477 is a potent and selective MCL-1 inhibitor. |
|
| DC9296 |
A-1331852
Featured
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A-1331852 is a high affinity BH3 mimetic Ligand of BCL protein BCL-XL. |
|
| DC12702 |
A1874
Featured
|
A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells). |
|
| DC10509 |
A-196
Featured
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A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. |
|
| DC9574 |
A-317491 (sodium salt hydrate)
Featured
|
A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. |
|
| DC7855 |
A-366
Featured
|
A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50 = 3.3 nM). |
|
| DC12659 |
A-381393
Featured
|
A-381393 is a potent and selective agonist of the dopamine D4 receptor. |
|
| DC10129 |
A395
Featured
|
A-395 potently inhibited the formation of H3K27me3 (via antagonizing EED in the trimeric PRC2 complex (EZH2:EED:SUZ12)) with IC50 = 34 ± 2 nM (Hill Slope = 0.7) |
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