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Cat. No. Product name CAS No.
DC7970 ACT058362 (Palosuran) Featured

Palosuran (ACT-058362) is a new potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM.

540769-28-6
DC8459 Palovarotene(R 667) Featured

Palovarotene (R-667, RO-3300074) is a selective retinoic acid receptor gamma(RAR-γ) agonist for the treatment of emphysema.

410528-02-8
DC9681 Pamapimod(R-1503) Featured

Pamapimod(R-1503)is a novel p38 MAP kinase inhibitor.

449811-01-2
DC20769 Pamiparib Featured

Pamiparib (BGB-290, BGB290) is a highly potent, selective and brain penetrant PARP1/2 inhibitor with potent anti-tumor activity.

1446261-44-4
DC7183 Panobinostat(LBH589) Featured

Panobinostat(LBH-589) is a broad-spectrum HDAC inhibitor; low nanomolar concentrations (IC50=5-20 nM) of LBH589 induced cell-cycle arrest, apoptosis, and histone (H3K9 and H4K8) hyperacetylation in MOLT-4 and Reh cell.

404950-80-7
DC20234 PAQ Featured

PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells.

943902-10-1
DC10875 Paquinimod Featured

Paquinimod is a S100A9 inhibitor, which prevents S100A9 binding to TLR-4.

248282-01-1
DC9675 Pardoprunox.HCl(SLV-308) Featured

Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist.

269718-83-4
DC6911 pardoprunox (SLV308) Featured

Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist; D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA

269718-84-5
DC10604 PARGYLINE HYDROCHLORIDE Featured

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO; Kis = 15 and 1.8 μM for MAO-A and MAO-B, respectively).

306-07-0
DC10893 Parimifasor Featured

Parimifasor is an immunomodulator, with anti-inflammatory activity.

1796641-10-5
DC9098 Paroxetine HCl Featured

Paroxetine hydrochloride hemihydrate is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).

110429-35-1
DC11445 Parthenolide Featured

Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium).

20554-84-1
DC9865 Paulownin Featured

Paulownin can highly inhibit the growth of H. pylori and exhibits strong inhibitory specificity against H. pylori related to E. coli.

13040-46-5
DC21457 Pax2 inhibitor EG1 Featured

Pax2 inhibitor EG1 (EG1) is a potent, small molecule inhibitor of Pax2 mediated transcription activation, effectively blocks Pax2 activity and DNA binding with Kd of 1.35-1.5 uM; inhibits Pax2 mediated expression with IC50 of 10 uM, and inhibits proliferation of Pax2 positive renal and ovarian cancer cell lines but has little effect on Pax2 negative cancer cells; inhibits embryonic kidney development.

693241-54-2
DC9776 Pazopanib Hydrochloride Featured

Pazopanib Hcl (GW-786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.

635702-64-6
DC2600 Pazopanib Featured

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit.

444731-52-6
DC10157 PAβN dihydrochloride Featured

PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.

100929-99-5
DC7550 PBIT Featured

PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro.

2514-30-9
DC22191 PBT434 Featured

PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease; inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein, a protein that aggregates in the neuropathology; prevents loss of substantia nigra pars compacta neurons (SNpc), lowers nigral α-synuclein accumulation, and rescues motor performance in mice model of PD.

1232841-78-9
DC9723 PBTZ169 Featured

PBTZ169 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor.

1377239-83-2
DC11770 PC786 Featured

PC786 (PC-786) is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 2.1 nM and 0.5 nM in cell-free enzyme assay and mini-genome assay in HEp-2 cells, respectively.

1902114-15-1
DC10757 PCI-29732 Featured

PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.

330786-25-9
DC8844 PCI-27483 Featured

PCI-27483 is a selective small molecule inhibitor of activated coagulation factor VII (FVIIa), which is in preclinical development as a novel anti-cancer agent.

871266-63-6
DC1106 PCI-32765 (Ibrutinib) Featured

PCI-32765 (Ibrutinib) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM.

936563-96-1
DC1109 PCI-34051 Featured

PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM.

950762-95-5
DC10531 PCO371 Featured

PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1.

1613373-33-3
DC7224 PD 123319 Featured

PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

136676-91-0
DC8283 PD 150606 Featured

PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively).

179528-45-1
DC8747 PD-151746 Featured

PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.

179461-52-0
DC8078 PD 153035(AG-1517) Featured

PD 153035(AG-1517) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFRK), with an IC50 of 25 pM.

153436-54-5
DC5100 PD 98059 Featured

PD 98059 is a selective inhibitor of MEK and blocker of MAPK

167869-21-8
DC9744 PD0166285 Featured

PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.

185039-89-8
DC1056 PD0325901 (Mirdametinib) Featured

PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.

391210-10-9
DC9280 BMS-1 (PD1/PDL1 inhibitor 1) Featured

PD-1/PD-L1 inhibitor 1 is a PD-1/PD-L1 interaction inhibitor,IC50 values: 0.006-0.10 μM,a useful immunomodulator compound.

1675201-83-8
DC8381 PD-1/PD-L1 inhibitor 2(BMS-202) Featured

PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM,a useful compound immunomodulator compound.

1675203-84-5
DC5021 PD153035 HCl (SU-5271, AG1517) Featured

PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src.

183322-45-4
DC7842 PD158780 Featured

PD158780 is a very potent inhibitor of EGFR with IC50 of 0.08 nM; pan-specific antagonist of ErbB receptor.

171179-06-9
DC21466 PD166285 Featured

PD166285 (PD 0166285) is a broad-spectrum receptor tyrosine kinase (RTK) inhibitor that inhibits PDGFR-β, EGFR, and FGFR1 and c-Src with IC50 of 7-85 nM.

212391-63-4
DC10068 PD166866 Featured

PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.

192705-79-6
DC12316 PD-168077 maleate Featured

PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.

630117-19-0
DC9258 PD168393 Featured

PD168393 is potent, cell-permeable, irreversible and selective inhibitor of EGF receptor (EGFR) tyrosine kinase and ErbB2.

194423-15-9
DC5095 PD169316 Featured

PD169316 is a potent and selective p38 MAP kinase inhibitor

152121-53-4
DC2054 PD-173074 Featured

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.

219580-11-7
DC7571 PD173955 Featured

PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth.

260415-63-2
DC8744 PD318088 Featured

PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.

391210-00-7
DC21467 PDD 00017273 Featured

PDD 00017273 is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM.

1945950-21-9
DC10904 PDM2 Featured

PDM 2 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM.

688348-25-6
DC8168 Peficitinib(ASP015K,JNJ-54781532) Featured

Peficitinib(ASP015K,JNJ-54781532) is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats.

944118-01-8
DC7225 Pelitinib (EKB-569; WAY-EKB 569) Featured

Pelitinib (EKB-569; WAY-EKB 569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM.

257933-82-7
DC11360 Pemafibrate Featured

Pemafibrate is an orally bioavailable and selective agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 1 nM for transcriptional activity), a transcription factor that is essential for regulation of lipid homeostasis.

848259-27-8
DCAPI1528 Pemetrexed Disodium Hemipentahydrate Featured

Pemetrexed Disodium Hemipentahydrate

357166-30-4
DC8149 Pemetrexed disodium Featured

Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

150399-23-8
DC12178 Pemigatinib Featured

Pemigatinib is a selective FGFR inhibitor in development for the treatment of patients with cholangiocarcinoma.

1513857-77-6
DC10507 Pentamidine dihydrochloride Featured

Pentamidine Dihydrochloride(MP601205 dihydrochloride) is an antimicrobial agent.

50357-45-4
DC7041 Pentostatin(Deoxycoformycin) Featured

Pentostatin(Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM).

53910-25-1
DC12194 PEO-IAA Featured

PEO-IAA is an indole-3-acetic acid (IAA) antagonist. PEO-IAA is an auxin antagonist that binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs).

6266-66-6
DC7989 PEPA Featured

PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.

141286-78-4
DC21021 Peptide P60 Featured

Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3; inhibits murine and human-derived Treg and improves effector T cell stimulation, overcomes the inhibitory effect of FOXP3 on the activity of the transcription factors NF-κB and NFAT, inhibits upregulation of mRNA for Foxp3 and IL-10 on effector T cells and enhances mRNA for IFN-γ after anti-CD3 stimulation; induces a scurfy-like disease in newborn mice, improves vaccine efficacy in mice model of CT26 tumor and HCV infection.

1319725-20-6
DCAPI1010 Peramivir Trihydrate Featured

Peramivir, also known as BCX1812 and RWJ 270201, is an antiviral drug for the treatment of influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. Peramivir was approved to treat influenza infection in adults.

1041434-82-5
DC7226 Perampanel(E2007) Featured

Perampanel(E2007; ER 155055-90) is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials.

380917-97-5
DC21821 Perhexiline maleate Featured

Perhexiline maleate (WSM 3978G) is a prophylactic antianginal agent that inhibits carnitine palmitoyltransferase (CPT1/CPT2).

6724-53-4
DC2021 Perifosine (KRX-0401) Featured

Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM.

157716-52-4
DC12059 Pertussis Toxin Featured

Pertussis Toxin is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough.

70323-44-3
DC22930 PF-4878691 (3M-852A) Featured

PF 04878691 (PF 4878691, S 32865, 852A, 3M 001) is a selective TLR7 agonist that potently induces IFN-α and IFN-regulated proteins from human PBMC.

532959-63-0
DC10529 PF 05089771 Featured

PF 05089771 is a Nav1.7 channel blocker extracted from patent WO/2010/079443 A1, compound example 788, has an IC50 of 8.6 nM.

1235403-62-9
DC10496 PF06260933 Featured

PF 06260933 is a potent and selective MAP4K4 inhibitor (IC50 value 3.7 nM for MAP4K4 a.k.a. HGK or ZC1) with suitable PK properties in mouse to be used as a tool in an in vivo model of diabetes, vascular inflammation and atherosclerosis.

1811510-56-1
DC7691 PF 1022A Featured

PF 1022A is a N-methylated cyclooctadepsipeptides (CODPs) with strong anthelmintic properties; acts as an ionophore.

133413-70-4
DC8259 PF0477736 Featured

PF 477736 is a CHK inhitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively. A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity

952021-60-2
DC4106 PF573228 Featured

PF 573228 is a inhibitor of FAK with IC50 of 4 nM.

869288-64-2
DC21477 PF 6260933 dihydrochloride Featured

PF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM.

1883548-86-4
DC2086 PF-670462 Featured

PF 670462 is a selective casein kinase, CK1ε and CK1δ inhibitor which also shows potency against 42 other kinases.

950912-80-8
DC20027 PF 750 Featured

PF 750 is a selective and covalent fatty acid amide hydrolase (FAAH) inhibitor, with IC50s varied from 16.2-595 nM in different pre-incubation times. Covalently modifies the enzyme’s active site serine nucleophile.

959151-50-9
DC3168 PF-562271 PHSO3H SALT Featured

PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.

939791-38-5
DC10038 PF-01247324 Featured

PF-01247324 is an orally bioavailable, selective and potent NaV1.8 channel blocker that inhibits that exhibits analgesic efficacy in rodent behavioral models of pain.

875051-72-2
DC8382 PF-03084014 (Nirogacestat) Featured

PF-03084014 (PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Phase 2.

1290543-63-3
DC21483 PF03715455 Featured

PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC50 values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease)[1][2].PF-03715455 is a moderate inhibitor of CYP1A2, CYP2C19, and CYP2D6 and a potent inhibitor of CYP’s 2C9 and CYP3A4[2].PF-03715455 treatment shows that the Vss and T1/2 are 0.19 L/kg, 1 hour, respectively[2]. Animal Model: Male CD Sprague Dawley rats (300-450 g)[2] Dosage: 1 mg/kg Administration: I.v. (Pharmacokinetic Analysis) Result: The Vss, and T1/2 were 0.19 L/kg, 1 hour, respectively.

1056164-52-3
DC7059 PF-03758309 Featured

PF-03758309 is an orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity.

898044-15-0
DC24071 PF-04217903 methanesulfonate Featured

PF-04217903 is a potent, selective, ATP-competitive c-Met kinase inhibitor with Ki of 4.8 nM, inhibits HGF-stimulated tyrosine phosphorylation of wild type c-Met with IC50 of 7.3 nM in cell-based assays.

956906-93-7
DC7081 PF-04217903 Featured

PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant).

956905-27-4
DC8353 PF-04418948 Featured

PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM).

1078166-57-0
DC11367 PF-04447943 Featured

PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis.

1082744-20-4
DC7027 Glasdegib(PF-04449913) Featured

PF-04449913 is a potent and orally bioavailable inhibitor of smoothened with IC50 of 5 nM(Gli-luciferase reporter reporter in C3H10T1/2); the hedgehog pathway inhibitor

1095173-27-5
DC9442 PF-04457845 Featured

PF-04457845 is a potent and exquisitely selective inhibitor of FAAH, with an IC50 of 7.2 nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen.

1020315-31-4
DC7227 PF-04620110 Featured

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

1109276-89-2
DC23600 PF-04856264 Featured

PF-04856264 is a potent, selective Nav1.7 blocker with IC50 of 28 nM, dispalys >1,000-fold selectivity over Nav1.5.

1235397-05-3
DC8727 PF-04880594 Featured

PF-04880594 is an inhibitor of RAF with IC50 values of 0.19 nM/0.13 nM and 0.39 nM for BRAF/BRAFV599E and c-RAF, respectively.

1111636-35-1
DC9948 SNX-5422(PF04929113) Featured

PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor (Kd of 41 nM). PF-04929113 also inhibits Her-2 degradation (IC50 of 37 nM).

908115-27-5
DC20164 PF-04965842 (Abrocitinib) Featured

PF-04965842 is a potent JAK1 inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively.

1622902-68-4
DC3108 PF-04971729 (Ertugliflozin) Featured

PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2, is currently in phase 2 trials for the treatment of diabetes mellitus.

1210344-57-2
DC9915 PF04995274,PF 04995274 Featured

PF-04995274 is a 5-HT4 receptor partial agonist. It thought to act centrally as a pro-cognitive agent that being developed for the treatment of Alzheimer's disease (AD).

1331782-27-4
DC21475 PF-05105679 Featured

PF-05105679 is a potent, selective TRPM8 channel inhibitor with IC50 of 103 nM (human TRPM8 currents inhibition).

1398583-31-7
DC21486 PF-05150122 Featured

PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5..

1235406-03-7
DC10050 PF05175157 Featured

PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively.

1301214-47-0
DC11937 PF 05180999 Featured

PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.

1394033-54-5
DC26091 PF-05198007 Featured

PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, no significant activity against Nav1.5 (IC50>10 uM).

1235406-19-5
DC20145 PF-05231023 Featured

PF-05231023, a long-acting fibroblast growth factor 21 (FGF21) analog, is a FGF21-receptor agonist, suitable for development as a potential treatment for T2DM.

1037589-69-7
DC21476 PF-05381941 Featured

PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively, with good kinome selectivity against 50 representative kinases.

1474022-02-0
DC12518 PF-06256142 Featured

PF-06256142 (PF06256142) is a potent and selective orthosteric agonist of the D1 receptor with EC50 (cAMP) of 33 nM, shows exquisitely selectivity over D2.

1609583-14-3
DC10500 PF-06282999 Featured

PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases.

1435467-37-0
DC12594 PF-06305591 Featured

PF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels.

1449473-97-5
DC21488 PF-06372865 Featured

PF-06372865 is a novel potent, α2/3 functionally selective GABAA receptor positive allosteric modulator.

1614245-70-3
DC11466 PF-06409577 Featured

PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.

1467057-23-3
DC22780 PF-06446846 hydrochloride Featured

PF-06446846 (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells.

1632250-50-0
DC22783 PF-06446846 Featured

PF-06446846 (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells.

1632250-49-7
DC7971 PF-06447475 Featured

PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.

1527473-33-1
DC11288 PF-06454589 Featured

PF-06454589 is a potent and selective LRRK2 inhibitor.

1527473-30-8
DC7924 PF06463922(Lorlatinib) Featured

PF06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.

1454846-35-5
DC21501 PF-06648671 Featured

PF-06648671 is a potent γ-secretase modulator with IC50 of 8.9 nM against Aβ42. PF-06648671 has favorable brain availability in rodent, which translated into excellent central exposure in human and robust reduction of amyloid β (Aβ) 42 in cerebrospinal fluid (CSF).

1587727-31-8
DC24082 PF-06650833 Featured

PF06650833 is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. PF06650833 is used to treat diseases such as rheumatoid arthritis, l

1817626-54-2
DC10779 PF-06651600 Featured

PF-06651600 is a potent JAK3-selective inhibitor with an IC50 of 33.1 nM.

1792180-81-4
DC12489 PF-06700841 free base Featured

PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus.

1883299-62-4
DC12488 PF-06700841 tosylate Featured

PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus.

2140301-96-6
DC20067 PF-06737007 Featured

PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.

1863905-38-7
DC10022 PF06840003 Featured

PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities.

198474-05-4
DC10834 PF-06869206 Featured

PF-06869206 is an Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1).

2227425-05-8
DC22194 PF-06873600 Featured

PF-06873600 (PF06873600, PF 06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively.

2185857-97-8
DC21478 PF-06928215 Featured

PF-06928215 (PF06928215) is a high affinity Cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 200 nM, IC50 of 4.9 uM.

2378173-15-8
DC2047 Crizotinib (PF-2341066) Featured

PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley.

877399-52-5
DC7201 PF-2545920(MP-10) Featured

PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM.

898562-94-2
DC1091 PF-299804 (Dacomitinib,PF-00299804) Featured

PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively.

1110813-31-4
DC7480 PF-3274167(cligosiban) Featured

PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM.

900510-03-4
DC23267 PF-3450074 Featured

PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro.

1352879-65-2
DC22797 PF-3644022 Featured

PF-3644022 is a potent and selective, freely reversible, ATP-competitive inhibitor of MAPKAP2 (MK2) with Ki of 3 nM.

1276121-88-0
DC8059 PF 429242 Featured

PF-429242 is a potent inhibitor of S1P(cellular proprotein convertase sterol regulatory element-binding protein (SREBP) site 1 protease)

947303-87-9
DC7941 PF-431396 Featured

PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor , PF-431396 has a Kd value of 445 nM for BRD4.

717906-29-1
DC8526 PF4618433 Featured

PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796.

1166393-85-6
DC7229 PF-4708671 Featured

PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), with a Ki of 20 nM and IC50 of 160 nM.

1255517-76-0
DC8395 PF-4989216 Featured

PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.

1276553-09-3
DC8146 PF-5006739 Featured

PF-5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε)

1293395-67-1
DC12373 PF-5274857 Featured

PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.

1373615-35-0
DC1107 PF-543 Featured

PF-543 is a novel Sphingosine kinase 1 (SphK1, SK1) inhibitor with Ki of 3.6 nM.

1415562-82-1
DC3169 PF-562271 Featured

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.

717907-75-0
DC21504 PF-719 Featured

PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells.

1404454-02-9
DC7247 PF-8380 Featured

PF-8380 is a potent and specofic autotaxin inhibitor with an IC50 value of 2.8 nM.

1144035-53-9
DC10783 PF-9366 Featured

PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM.

72882-78-1
DC9305 PF-CBP1(PF-06670910) hydrochloride Featured

PF-CBP1 is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons.

1962928-21-7
DC5025 PFI-1 (PF-6405761) Featured

PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM.

1403764-72-6
DC7679 (R)PFI-2 HCl Featured

PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets.

1627607-87-7
DC7649 PFI-3 Featured

PFI-3 is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains with IC50 ~ 89 nM and 48 nM respectively.

1819363-80-8
DC8291 PFI-4 Featured

PFI-4 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM).

900305-37-5
DC8026 PFK-015 Featured

PFK-015 is an effective inhibitor of PFKFB3 with IC50 of 110 nM (recombinant PFKFB3) and inhibits PFKFB3 activity in cancer cells with IC50 of 20 nM.

4382-63-2
DC10451 PFK158 Featured

PFK-158 is a potent and selective inhibitor of PFKFB3 that is currently being investigated in a phase I study in patients with advanced solid malignancies.

1462249-75-7
DC21665 PFM01 Featured

PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupt

1558598-41-6
DC12552 PGN9856 Featured

PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows higi selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors; displays a potency (pEC50 >8.5) and a maximal response (increase in cAMP) comp

863704-91-0
DC10794 PH-002 Featured

PH-002 is a small-molecule structure corrector,inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction,a potent candidate drug for the treament of AD(Alzheimer disease)

1311174-68-1
DC7727 PH-797804 Featured

PH-797804 is a potent and selective p38 inhibitor with IC50 of 26 nM.

586379-66-0
DC7230 PHA-665752 Featured

PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM, >50-fold selectivity for c-Met than RTKs or STKs.

477575-56-7
DC5111 PHA-680632 Featured

PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.

398493-79-3
DC8025 CAY10572(PHA-767491) Featured

PHA-767491 (CAY10572) is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor with IC50 values of 10/34 nM.

845714-00-3
DC4123 PHA-793887 Featured

PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM, respectively.

718630-59-2
DC7231 PHA-848125(Milciclib) Featured

PHA-848125(Milciclib) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM; >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7.

802539-81-7
DC9752 PHCCC Featured

PHCCC is a Group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM).

179068-02-1
DC10763 Philanthotoxin 74 (hydrochloride) Featured

Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively.

1227301-51-0
DC10645 Phorbol 12-myristate 13-acetate (PMA) Featured

Phorbol 12-myristate 13-acetate (PMA) is a PKC-activating phorbol ester, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM.

16561-29-8
DC7481 PHT427 Featured

PHT-427 is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with Ki of 2.7 μM and 5.2 μM, respectively.

1191951-57-1
DC10846 PHTPP Featured

PHTPP is a pyrazolo[1,5-α]pyrimidine-based ligand that acts as a full antagonist of estrogen ERβ receptors with 36-fold selectivity over ERα.

805239-56-9
DC23040 Jatrorrhizine Featured

Phytochemical alkaloid found in medicinal plants. Anti-inflammatory. Exhibits neuroprotective, antioxidative and gastrointestinal modulatory activities.

3621-38-3
DC7232 PI-103 Featured

PI103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha (IC50= 2 nM), p110beta (IC50= 3 nM), p110delta (IC50= 3 nM), and p110gamma (IC50= 15 nM), less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM.

371935-74-9
DC9611 PI-1840 Featured

PI-1840 is a potent and selective inhibitor for chymotrypsin-like (CT-L) (IC50 value = 27 ± 0.14 nM) over trypsin-like and peptidylglutamyl peptide hydrolyzing (IC50 values >100 μM) activities of the proteasome.

1401223-22-0
DC7628 PI-3065 Featured

PI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR.

955977-50-1
DC20036 PI3K/mTOR Inhibitor-2 Featured

PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR. Antitumor activity.

1848242-58-9
DC8335 PQR-309(Bimiralisib) Featured

PI3K-IN-2 is a PI3K inhibitor, inhibits pPKB and pS6 with "++++/+++(+)" in A2058 melanoma cell.

1225037-39-7
DC8531 TASP0415914 Featured

PI3Kγ is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP0415914 has shown excellent results in cell based assays. It is orally av

1292300-75-4
DC20008 PI3Kδ-IN-1 Featured

PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC50 of 1.7 nM.

1911564-39-0
DC9318 Piboserod Featured

Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.

152811-62-6
DC10728 Pibrentasvir(ABT-530) Featured

Pibrentasvir is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50s ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.

1353900-92-1
DC8426 Picropodophyllin (PPP) Featured

Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM.

477-47-4
DCAPI1426 Pidotimod Featured

Pidotimod is a synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses. This compound has been shown to induce dendritic cell maturation and up-regulate the expression of HLA-DR and co-stimulatory molecu

121808-62-6
DC9505 Pifithrin-α (hydrobromide) Featured

Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.

63208-82-2
DC8144 Pifithrin-β (hydrobromide) Featured

Pifithrin-β HBr (Cyclic Pifithrin-α HBr) is a potent p53 inhibitor with IC50 of 23 uM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1.

511296-88-1
DC7233 Pifithrin-u Featured

Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.

64984-31-2
DC9661 PIK-293 Featured

PIK-293 is a PI3K inhibitor, mostly for PI3Kδ with IC50 of 0.24 μM, 500-, 100- and 50-fold less potent to PI3Kα/β/γ, respectively.

900185-01-5
DC7234 PIK-294 Featured

PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively.

900185-02-6
DC7235 PIK-75 Featured

PIK-75 is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM.

372196-77-5
DC1096 PIK90 Featured

PIK-90 is a potent and cell permeable inhibitor of p110α, p110β, p110γ and p110δ with IC50 of 11 nM, 350 nM, 18 nM and 58 nM, respectively.

677338-12-4
DC8254 PIK-93 Featured

PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.

593960-11-3
DC9747 PIK-III Featured

PIK-III, which is a selective inhibitor of ​VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates.

1383716-40-2
DC8184 Pilaralisib(XL-147; SAR245408) Featured

Pilaralisib (SAR245408; XL147) is selective oral pan-PI3K inhibitor.

934526-89-3
DC9593 Pim1/AKK1-IN-1 Featured

PIM/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively; also inhibits MPSK1 and TNIK.

1093222-27-5
DC10047 PIM-447 dihydrochloride Featured

PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase.

1820565-69-2
DC8795 Pimavanserin(ACP-103) Featured

Pimavanserin(ACP-103) is a potent and selective 5-HT2A receptor inverse agonist with mean pIC50 of with 8.7 in the cell-based functional assay.

706779-91-1
DC8243 Pimecrolimus Featured

Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.

137071-32-0
DC8661 Pimelic Diphenylamide 106(TC-H 106) Featured

Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs.

937039-45-7
DC7236 Pimobendan Featured

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.

74150-27-9
DC9815 Pimodivir(VX-787) Featured

Pimodivir(VX-787) is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. 

1629869-44-8
DC20505 Pimozide Featured

Pimozide is an antipsychotic agent that acts as an antagonist of the D2, D3, and D4 receptors and the 5-HT7 receptor, also is an inhbitor of STAT5.

2062-78-4
DC12096 Pinacidil monohydrate (Pinacidil hydrate) Featured

Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator.

85371-64-8
DCAPI1413 pioglitazone hydrochloride Featured

Pioglitazone Hydrochloride is the hydrochloride salt preparation of Pioglitazone, a specific ligand of PPAR-γ (peroxisome proliferator-activated receptor-γ). Pioglitazone is a thiazolidinedione compound described to produce antiinflammatory and antiarteri

112529-15-4
DC10113 Pipequaline Featured

Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.

77472-98-1
DC24186 Piperazine Erastin Featured

Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death..

1538593-71-3
DC9691 Piperlongumine Featured

Piperlongumine induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53.

20069-09-4
DC10115 Piperoxan hydrochloride Featured

Piperoxan hydrochloride is an α2 adrenoceptor antagonist.

135-87-5
DC8112 Pirarubicin(THP) Featured

Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.

72496-41-4
DC8792 Pirfenidone(AMR69) Featured

Pirfenidone(AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Phase 3.

53179-13-8
DC10012 Pirmenol hydrochloride Featured

Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.

61477-94-9
DC10364 (±)-Pirmenol Featured

Pirmenol inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.

68252-19-7
DC7155 Pirodavir (R 77975) Featured

Pirodavir (R 77975) is the prototype of a novel class of broad-spectrum antipicornavirus compounds; potent human rhinovirus (HRV) capsid-binding inhibitor.

124436-59-5
DCAPI1470 Pitavastatin Calcium Featured

Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH o

147526-32-7
DC9465 Pitolisant (hydrochloride) Featured

Pitolisant Hcl(BF2.649;Ciproxidine ) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM).

903576-44-3
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