| DC23996 |
Capadenoson
Featured
|
Capadenoson is a selective agonist of adenosine-A1 receptor. |
|
| DC22954 |
MG-624
Featured
|
MG624 is a potent and selective neuronal α7 nAChR antagonist with a Ki of 106 nM. |
|
| DC21853 |
Ogerin
Featured
|
A selective GPR68 positive allosteric modulator (pEC50=6.83) with minimal PAM activity at the related proton-sensing GPCRs GPR4 and GPR65. |
|
| DC26069 |
SR-11237
Featured
|
SR-11237 is a selective pan retinoid X receptor (RXR) agonist with no retinoid A receptor (RAR) activity. . |
|
| DC22616 |
CJ-42794
Featured
|
A selective prostaglandin E receptor subtype 4 (EP4) antagonist with pKi of 8.5. |
|
| DC12013 |
NSC45586
Featured
|
A selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2. |
|
| DC22924 |
3M-002
Featured
|
A selective TLR8 agonist that induces activation of NF-κB at 0.4 uM. |
|
| DC20306 |
AMTB hydrochloride
Featured
|
A selective TRPM8 channel blocker with pEC50 of 6.91 in Ca(2+) influx assay, with no activity for TRPV4 (pEC50<4.6). |
|
| DC7029 |
SC-26196
Featured
|
A selective Δ6 desaturase inhibitor that displays selectivity over Δ5 and Δ9 desaturases |
|
| DCAPI1468 |
Rosuvastatin Calcium
Featured
|
A selective, competitive inhibitor of HMG-CoA reductase, that is also antilipemic. |
|
| DC23981 |
BCX-1470 methanesulfonate
Featured
|
A serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM). |
|
| DC25021 |
Endosidin-2
Featured
|
A small molecule binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex (Kd=253 uM), resulting in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking.. |
|
| DC9867 |
prostaglandin D2（PGD2) inhibitor
Featured
|
A small molecule compound of prostaglandin D2（PGD2) inhibitor. |
|
| DC12003 |
Corr4A
Featured
|
A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM.. |
|
| DC22843 |
DDX3-IN-16d
Featured
|
A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3), a human host factor required for the replication of several DNA and RNA viruses. |
|
| DC11645 |
Pitstop 2
Featured
|
A small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis. |
|
| DC23010 |
R-59949(R-59-949)
Featured
|
A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets. |
|
| DC23017 |
R 59022
Featured
|
A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets. |
|
| DC22761 |
NCI-83633
Featured
|
A small molecule inhibitor of PP2C that activates extensive 3' cleavage at a concentration 50-fold below that required by fluoride or CP.. |
|
| DC22552 |
IC-87201
Featured
|
A small molecule inhibitor of PSD-95/nNOS interaction with IC50 of 31 uM, without inhibiting nNOS catalytic activity. |
|
| DC22984 |
IT-603
Featured
|
A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays. |
|
| DC22833 |
KKL-35
Featured
|
A small molecule inhibitor of trans-translation that has broad-spectrum antibiotic activity. |
|
| DC22832 |
Filastatin
Featured
|
Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect. |
|
| DC23982 |
Navoximod (GDC-0919; NLG-919)
Featured
|
Navoximod (GDC-0919; NLG-919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. |
|
| DC23762 |
PDI inhibitor 16F16
Featured
|
PDI inhibitor 16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation. |
|
| DC23210 |
SZL P1-41
Featured
|
A small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro. |
|
| DC20527 |
Ractopamine
Featured
|
A small molecule TAAR1 agonist and β adrenoreceptor agonist that stimulates β1 and β2 adrenergic receptors. |
|
| DC11926 |
NDMC101
Featured
|
A small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo. |
|
| DC21418 |
NSC 243928
Featured
|
NSC243928(NSC-243928 ) is a small molecule that potently inhibit ovarian cancer stem-like cells (CSC) growth with GI50 of 0.83 uM, which os consistent with cell death/apoptosis.. |
|
| DC22777 |
FPH 2(BRD9424)
Featured
|
A small molecule that promotes differentiation of iPS-derived hepatocytes. |
|
