| DC60145 |
GW805758X
Featured
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GW805758X is a potent inhibitor of CDK-4 which demonstrates enzyme selectivity against VEGFR-2 and GSK3β. |
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| DC60146 |
BTA-EG4 hydrate
Featured
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BTA-EG4, acts as an amyloid-binding small molecule that promotes dendritic spine density and cognitive function in wild-type mice. |
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| DC60148 |
Coumarin-TMP-Halo
Featured
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Coumarin-TMP-Halo is a specific fluorescent protein labeling agent. |
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| DC60149 |
1-Boc-1,8-diaminooctane
Featured
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tert-butyl (8-aminooctyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs. tert-butyl (8-aminooctyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine. |
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| DC60150 |
S-[2-(4-Pyridyl)ethyl]-L-cysteine
Featured
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| DC60151 |
TET-IN-C35
Featured
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| DC60152 |
SHIN 2, SHIN-2
Featured
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SHIN-2 is a novel SHMT inhibitor, increasing survival in NOTCH1-driven mouse primary T-ALL in vivo |
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| DC60153 |
2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one
Featured
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2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one is an human neutrophil elastase inhibitor. |
|
| DC60154 |
Miclxin
Featured
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Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells |
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| DC46982 |
Setmelanotide acetate
Featured
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Setmelanotide (RM-493, BIM-22493, CAM 4072) is a cyclic peptide full agonist of melanocortin-4 receptor (MC4R) with an EC50 of 0.27 nM and a Ki of 2.1 nM. |
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| DC46984 |
Lonodelestat
Featured
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Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). |
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| DC46999 |
Sec61-IN-1
Featured
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Sec61-IN-1 is a potent sec61 inhibitor (Patent WO2020176863A1, compound A317). |
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| DC47003 |
Bevurogant
Featured
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Bevurogant is a retinoid-related orphan receptor-gamma t (RORγt) antagonist. Bevurogant can be used for the research of chronic inflammatory diseases. |
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| DC47009 |
Zabedosertib
Featured
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Zabedosertib (BAY 1834845) is a IRAK4 inhibitor with immunomodulatory potential. IRAK4 is a protein kinase involved in signaling innate immune responses from Toll-like receptors. |
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| DC47017 |
Vibozilimod
Featured
|
Vibozilimod (example 33) is a S1p1 receptor agonist (extracted from patent WO2012140020A1). |
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| DC47029 |
Selnoflast
Featured
|
Selnoflast (example 6) is a NLRP3 inhibitor (extracted from patent WO2019008025). |
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| DC47030 |
Ilunocitinib
Featured
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Ilunocitinib (compound 27) is a JAK inhibitor (extracted from patent WO2009114512A1). |
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| DC47038 |
Fosifidancitinib
Featured
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Fosifidancitinib is a potent and selective inhibitor of JAK kinases 1/3. Fociatinib is used in studies of allergies, asthma and autoimmune diseases. |
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| DC47048 |
Rebamipide mofetil
Featured
|
Rebamipide mofetil is an orally active prodrug of Rebamipide (OPC12759). Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner. |
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| DC47051 |
Temgicoluril
Featured
|
Tetramethylglycerol (Tetramethylglycoluril) is a small molecule that acts on GABA Receptor, with anti-anxiety activity. |
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| DC47053 |
Tigulixostat
Featured
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Tigulixostat is a novel (indolyl)heteroarylcarboxylate derivatives effective as non-purine selective xanthine oxidase inhibitor, which lowers the production of uric acid. |
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| DC47057 |
Vazegepant
Featured
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Vazegepant is the first intranasal CGRP receptor antagonist for the study the acute research of migraine. |
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| DC47060 |
Ansofaxine
Featured
|
Ansofaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for the research of depression. |
|
| DC47062 |
Bersacapavir
Featured
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Bersacapavir is a novel Hepatitis B Virus capsid assembly modulator. |
|
| DC47066 |
Ifidancitinib
Featured
|
Ifidancitinib is a potent and selective inhibitor of JAK kinases 1/3. Ifidancitinib can be used in studies of allergies, asthma and autoimmune diseases. |
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| DC47069 |
Ninerafaxstat
Featured
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Ninerafaxstat hifts cellular metabolism from fatty acid oxidation to glucose oxidation.Ninerafaxstat decreases fatty acid oxidation and improve overall mitochondrial respiration.Ninerafaxstat inhibit the growth and proliferation of cancer cells. |
|
| DC47080 |
Velufenacin
Featured
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Velufenacin is a muscarinic receptor antagonist. |
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| DC47084 |
Abrucomstat
Featured
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Abrucomstat (3-Nitroxypropanol) acts as an enzyme inhibitor to decrease ruminal methanogenesis. |
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| DC47090 |
Etavopivat
Featured
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Etavopivat is a potent, selective, orally bioavailable red blood cell (RBC) pyruvate kinase (PKR) activator. Etavopivat has potent antisickling effects. |
|
| DC47093 |
Fosciclopirox
Featured
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Fosciclopirox suppresses growth of urothelial cancer by targeting the γ-secretase complex. Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), to the entire urinary tract. Ciclopirox has anticancer activity in a number of solid and hematologic malignancies. |
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