EGPI-1|CAS 2355263-33-9|DC Chemicals

Cas No.:	2355263-33-9
Chemical Name:	EGPI-1
Synonyms:	EGPI 1;Benzaldehyde, 3,4-difluoro-, 2-[4-[4-(trifluoromethyl)phenyl]-2-thiazolyl]hydrazone, [C(E)]-
SMILES:	C1=C(/C=N/NC2SC=C(N=2)C2C=CC(C(F)(F)F)=CC=2)C=CC(F)=C1F
Formula:	C₁₇H₁₀F₅N₃S
M.Wt:	383.34
Purity:	>97%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Lijun Wang, et al. Eur J Med Chem. 2019 Sep 1;177:153-170. 2. Qi X, et al. Chem Biol Interact. 2022 Jan 25;352:109773.

Description:

EGPI-1 is a potent small molecule that inhibits the translation initiation factors eIF4E/eIF4G interaction.EGPI-1 has potent antiproliferative and proapoptotic activity in multiple myeloma cells, Jurkat cells, and A549 lung cancer cell lines, inhibts A549 proliferation with IC50 of 2.61 uM, which is better than that of 4EGI-1 (IC50=58.6 uM), inhibits cancer cell growth by inhibiting eIF4E phosphorylation and inhibiting PI3K/Akt/mTOR signal pathway.EGPI-1 induces autophagy, apoptosis, G0/G1 cell cycle arrest and ROS generation in A549 cells, disrupts the mitochondrial membrane potential (∆ψ m).EGPI-1 demonstrated in vivo anti-tumor activities in A549-xenografted athymic mice (25 mg/kg/day, 50 mg/kg/day, i.p.).

References:

1. Lijun Wang, et al. Eur J Med Chem. 2019 Sep 1;177:153-170. 2. Qi X, et al. Chem Biol Interact. 2022 Jan 25;352:109773.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC70380	EGPI-1	EGPI-1 is a potent small molecule that inhibits the translation initiation factors eIF4E/eIF4G interaction.EGPI-1 has potent antiproliferative and proapoptotic activity in multiple myeloma cells, Jurkat cells, and A549 lung cancer cell lines, inhibts A549 proliferation with IC50 of 2.61 uM, which is better than that of 4EGI-1 (IC50=58.6 uM), inhibits cancer cell growth by inhibiting eIF4E phosphorylation and inhibiting PI3K/Akt/mTOR signal pathway.EGPI-1 induces autophagy, apoptosis, G0/G1 cell cycle arrest and ROS generation in A549 cells, disrupts the mitochondrial membrane potential (∆ψ m).EGPI-1 demonstrated in vivo anti-tumor activities in A549-xenografted athymic mice (25 mg/kg/day, 50 mg/kg/day, i.p.).
DC40155	Zotatifin	Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM). Zotatifin induces cell apoptosis.
DC10415	4E2RCat	4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.