Cat. No. | Product name | CAS No. |
DC43923 |
RBC10
Featured
Novel inhibitor of the binding of Ral to its effector RALBP1, inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines |
362503-73-9 |
DC43932 |
Auxinole
Featured
Potent TIR1 antagonist, blocking the formation of the TIR1-IAA-Aux/IAA complex and so inhibiting auxin-responsive gene expressionReferences:1) Smékalová V, Luptovčiak I, Komis G, Šamajová O, Ovečka M, Doskočilová A, Takáč T, Vadovič P, Novák O, Pechan T, |
86445-22-9 |
DC43934 |
SIRT6-IN-5
Featured
Novel inhibitor of SIRT6, sensitizing pancreatic cancer cells to gemcitabineREFERENCES1) Damonte P, Sociali G, Parenti MD, Soncini D, Bauer I, Boero S, Grozio A, Holtey MV, Piacente F, Becherini P, Sanguineti R, Salis A, Damonte G, Cea M, Murone M, Poggi |
891002-11-2 |
DC43319 |
(S)-3,4-DCPG
Featured
Potent and selective mGluR8-specific orthosteric agonist |
201730-11-2 |
DC43940 |
Melittin
Featured
Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme. |
20449-79-0 |
DC43943 |
Gadobutrol
Featured
Gadobutrol (Gadovist, Gadavist) is a non-ionic macrocyclic gadolinium-based contrast agent (GBCA) that is usedfor tissue contrast enhancement in magnetic resonance imaging (MRI). |
770691-21-9 |
DC43957 |
Neophytadiene
Featured
Neophytadiene is a diterpene found in Turbinaria ornate, with anti-inflammatory antioxidant and cardioprotective properties. |
504-96-1 |
DC43960 |
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
Featured
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
1599440-25-1 |
DC43973 |
DL-TBOA ammonium
Featured
DL-TBOA ammonium is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA ammonium inhibits the uptake of [14C] |
2093503-71-8 |
DC43982 |
Enfumafungin
Featured
Enfumafungin, a triterpene glycoside, is isolated from extracts derived from an endophytic species of Hormonema. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis[1][2]. |
260979-95-1 |
DC43987 |
MCHR1 antagonist 2
Featured
MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells. |
863115-70-2 |
DC43994 |
SMS2-IN-1
Featured
SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM). |
2098890-15-2 |
DC43995 |
Conoidin A
Featured
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII). Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 µM. Conoidin A also inhibit |
18080-67-6 |
DC51000 |
Sisunatovir (Synonyms: RV521)
Featured
Sisunatovir (RV521), an orally available inhibitor of the RSV fusion (RSV-F) protein, exhibits potent efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses, with IC50s of 1.4 nM and 1.0 nM, respectively. |
1903763-82-5 |
DC51001 |
Sisunatovir HCl
Featured
Sisunatovir, also known as RV521, is a highly potent fusion inhibitor with efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses. RV521 exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection. Oral bioavailability in preclinical species ranged from 42 to >100% with evidence of highly efficient penetration into lung tissue. In healthy adult human volunteers experimentally infected with RSV, a potent antiviral effect was observed with a significant reduction in viral load and symptoms compared to placebo. |
1903763-83-6 |
DC51003 |
BMS-986224
Featured
BMS-986224 is a potent and selective apelin receptor (APJ) agonist with Ki of 0.074 nM, exhibiting similar receptor binding and signaling profile to (Pyr1) apelin-13. |
|
DC51005 |
BMS986313
Featured
BMS-986313 is a tricyclic-carbocyclic RORγt inverse agonist and shows potent GaL4-Luc reporter(GAL4) and human whole blood (hWB) activity (EC50s of 3.6 nM and 50 nM, respectively. |
|
DC51006 |
Lenalidomide-4-OH
Featured
A Novel PROTACs building block. |
1061604-41-8 |
DC51007 |
Lenalidomide-5-aminomethyl hydrochloride
Featured
Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC |
1158264-69-7 |
DC51010 |
CID 138454799
Featured
ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. |
2320561-35-9 |
DC51011 |
IXA6
Featured
IXA6 is a novel small molecule compound of inducing IRE1 RNase activity. |
1021106-40-0 |
DC51012 |
IXA4
Featured
IXA4 is the most selective for the IRE1–XBP1s signaling pathway.IXA4 selectively activate IRE1–XBP1s signaling and reduces secretion of APP through IRE1 activation. |
1185329-96-7 |