| DC65663 |
Melitane
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Acetyl hexapeptide-1 (Melitane) is a bioactive peptide with anti-wrinkle effect and has been reported used as a cosmetic ingredient. |
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| DC60498 |
UNC8153
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UNC8153 is a novel NSD2-targeted degrader that potently and selectively reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. |
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| DC65664 |
Palmitoyl tripeptide-38
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Palmitoyl tripeptide-38 is a bioactive peptide with anti-aging effect . |
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| DC65665 |
Palmitoyl Tripeptide-8
Featured
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Palmitoyl tripeptide-8 s a bioactive peptide with anti-allergen effect and has been reported used as a cosmetic ingredient. |
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| DC65666 |
Tripeptide-1
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| DC65667 |
AHK-Cu
Featured
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| DC65668 |
Mu-conotoxin
Featured
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μ-Conotoxin-CnIIIC is a 22-residue conopeptide that can be isolated from Conus consors. μ-Conotoxin-CnIIIC is a potent and persistent blocker of NaV1.4 channel. μ-Conotoxin-CnIIIC has analgesic, anaesthetic and myorelaxant properties. |
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| DC60499 |
C14-A1
Featured
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Lipid C14-A1 is an ionizable lipid. C14-A1-LPN is a potent and safe LNP platform to deliver Foxp3 mRNA to CD4+ T cells to engineer immunosuppressive FP3T cells. |
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| DC65669 |
TB500
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TB500 is a synthetic version of an active region of thymosin β4. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation. |
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| DC60500 |
NVS-STG2
Featured
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NVS-STG2 is a molecular glue that targets STING and activates STING-mediated immune signaling. NVS-STG2 induces higher-order oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models. |
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| DC65670 |
(2R)-N-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxopiperidine-1-carboxamide
Featured
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| DC65671 |
PROTAC BRAF-V600E degrader-1
Featured
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PROTAC BRAF-V600E degrader-1 is a potent PROTAC BRAF-V600E degrader with Kd value of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS). PROTAC BRAF-V600E degrader-1 can inhibit melanoma cell growth. |
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| DC65672 |
FASN-IN-5
Featured
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FASN-IN-5 (example 11), a FASN inhibitor, can be used for the research of TH17- or CSF1 -mediated disease or disorder such as cancer, immunological disorders, and obesity. |
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| DC65673 |
PAD-IN-2
Featured
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PAD-IN-2 is a potent pad4 inhibitor (IC50: <1 μM). PAD-IN-2 can be used in the research of auto-immune diseases and cancers, such as rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cystic fibrosis, asthma, multiple sclerosis and psoriasis. |
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| DC65675 |
4-Methylindoline
Featured
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| DC65676 |
Fenretinide Glucuronide Monosodium Salt
Featured
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Fenretinide Glucuronide Monosodium Salt, is the metabolite of Fenretinide (F250000), which is a synthetic retinoid deriverative, substances related to vitamin A. They are also shown to be used for the treatment of cancer, as well as in the treatment of cystic fibrosis, rheumatoid arthritis, acne, and psoriasis. |
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| DC65677 |
Lumigen APS-5
Featured
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Lumigen APS-5 is a substrate of alkaline phosphatase (ALP). Lumigen APS-5 can be used to assess the activity of alkaline phosphatase (ALP). |
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| DC60501 |
ABX-002
Featured
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ABX-002 is a novel CNS-penetrant TR-B agonist prodrug with significant potential for treating demyelinating disorders (e.g., multiple sclerosis), neuroinflammatory diseases (e.g., ALS, Alzheimer's), and neurodegenerative diseases (e.g., Parkinson's, Huntington's). Its ability to promote remyelination, reduce inflammation, and protect neurons makes it a promising therapeutic candidate for a range of CNS disorders. |
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| DC60502 |
GalNAc-Lipid GL6
Featured
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GalNAc-Lipid GL6 is a multi-valent N-acetylgalactosamine (GalNAc) targeting ligand. GalNAc-LNP is capable of delivering a CRISPR base editing therapeutic via LDLR-independent pathways. |
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| DC65679 |
BI-2493
Featured
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BI-2493 is a structural analogue of BI-2865 and a highly selective pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research. |
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| DC60503 |
Lipid C12-A1
Featured
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Lipid C12-A1 is an ionizable lipid. C12-A1-LPN is a potent and safe LNP platform to deliver Foxp3 mRNA to CD4+ T cells to engineer immunosuppressive FP3T cells. C12-A1 has a slightly lower average cell viability than C14-A1. |
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| DC65680 |
Lipid 2-10
Featured
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Lipid 2-10, an ionizable lipid with a pKa of 6.16, is utilized in the formulation of lipid nanoparticles (LNPs) featuring a bilayer structure. |
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| DC60504 |
RCS-03-104-4
Featured
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RCS-03-104-4 is a cysteine-reactive JQ1 analogue, which potently induces BRD4 degradation with DC50 and Dmax of 79 nM and 71%, respectively. RCS-03-104-4 causes BRD4 degradation by inducing its proximity with the ubiquitin ligase activity of DCAF11. |
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| DC65682 |
RCB-4-8
Featured
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RCB-4-8 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.1 RCB-4-8-containing LNPs improve lung transfection efficiency by approximately 100-fold over MC3-containing LNPs in mice. |
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| DC60506 |
IR-117-17
Featured
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IR-117-17 (A10-LIN) is an ionizable and biodegradable lipid specifically designed for nebulized mRNA delivery. When formulated into lipid nanoparticles (LNPs), IR-117-17 demonstrates remarkable efficacy, achieving a 300-fold enhancement in lung mRNA delivery compared to the best-performing LNP previously reported. Additionally, it shows a two-fold improvement over the leading PBAE-based delivery system, with up to a 45-fold increase in mRNA delivery efficiency to the large airways. |
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| DC65685 |
BODIPY 581/591 C11
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BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type). |
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| DC65686 |
Sotuletinib HCl
Featured
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Sotuletinib, also known as BLZ945, is a potent and selective CSF-1R kinase inhibitor. BLZ945 showed effects of CSF1R inhibition on other tumor-infiltrating immune cells. BLZ945 attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. BLZ945 decreases the growth of malignant cells in the mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinogenesis. BLZ945 prevents tumor progression in the keratin 14-expressing human papillomavirus type 16 (K14-HPV-16) transgenic model of cervical carcinogenesis. |
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| DC65687 |
Koenimbine
Featured
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Koenimbine is an anticancer agent that can be obtained from the leaves and fruits of Murraya koenigii. Koenimbine can induce apoptosis and necrosis in HT-29 and SW48 cells. Koenimbine can be used in the research of cancer. |
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| DC65688 |
Perlolyrin
Featured
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Perlolyrin (Tribulusterine) is an alkaloid that can be isolated from dried fruits of Tribulus terrestris. |
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| DC65689 |
PK-10
Featured
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PK-10 is a synergistic antibacterial agent of Fluconazole. |
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