| DC65690 |
SKF-91488 HCl
Featured
|
SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 microM. SKF 91488 dihydrochloride inhibits the methylation of labeled histamine in mice. |
|
| DC65691 |
CTL-06
Featured
|
CTL-06 is an inhibitor of Fatty Acid Synthase (FASN). |
|
| DC65692 |
CBiPES HCl
Featured
|
CBiPES hydrochloride is a mGlu2 receptor positive allosteric modulator (EC50: 92.8 nM). CBiPES hydrochloride attenuates stress-induced hyperthermia and PCP-induced hyperlocomotor activity. CBiPES hydrochloride can be used for research of neurological disease. |
|
| DC65693 |
TZ3O
Featured
|
TZ3O (compound TZ30) is an anticholinergic agent with neuroprotective effects. |
|
| DC65694 |
FZD7 antagonist F7H
Featured
|
F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM). Frizzled receptors (FZDs) influence Wnt signaling, mediating embryonic development and tissue homeostasis. F7H is a potent ligand for the FZD7 transmembrane domain (TMD). |
|
| DC65695 |
COH1 inhibitor
Featured
|
COH1 is a ribonucleotide reductase (RR) inhibitor. COH1 can be used in research into cancer, mitochondrial diseases, and neurodegenerative diseases. |
|
| DC65696 |
BML-278
Featured
|
BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 µM. |
|
| DC60507 |
CBD3063
Featured
|
CBD3063 is a selective, first-in-class, CRMP2-based peptidomimetic small molecule, which allosterically regulates Cav2.2 to achieve analgesia and pain relief without negative side effect profiles. |
|
| DC65697 |
HDAC6 inhibitor 4510
Featured
|
A novel and seletive HDAC6 inhibitor. |
|
| DC65698 |
4-Methylumbelliferyl a-D-Glucopyranoside
Featured
|
|
.png)
|
| DC60508 |
4A3-SCC-10
Featured
|
4A3-SCC-10 is a biodegradable ionizable lipid renowned for its exceptional endosomal escape and rapid mRNA release properties. When formulated into lipid nanoparticles (LNPs), it outperforms DLin-MC3-DMA, demonstrating an impressive 87-fold enhancement in mRNA delivery efficiency to the liver. |
|
| DC60509 |
4A3-SCC-PH
Featured
|
4A3-SCC-PH is a groundbreaking linker-degradable ionizable lipid (LDIL) that features a glutathione (GSH)-responsive cone-shaped molecular structure. This unique architecture enables superior endosomal escape and rapid mRNA release, making it highly effective for mRNA delivery. In vivo studies have highlighted its exceptional performance, showing a 176-fold increase in mRNA delivery efficiency to the liver compared to DLin-MC3-DMA, a widely used benchmark lipid. Both 4A3-SCC-PH and its structural analog, 4A3-SCC-10, also demonstrated significantly enhanced mRNA delivery efficacy compared to their non-disulfide-containing parent compounds and disulfide-containing controls with modified lipid tails. |
|
| DC65699 |
Mal-propyl-Ala-Ala-Asn-PAB
Featured
|
Mal-propyl-Ala-Ala-Asn(Trt)-PAB is a hetero bifunctional cross-linker, useful in antibody drug conjugation (ADC). |
|
| DC65700 |
SIALYLGLYCOPEPTIDE
Featured
|
Sialylglycopeptide is a complex N-glycan, bearing a short peptide fragment. Sialylglycopeptide, as a starting material for the semi-synthesis of N-glycans, can be used for various researches. |
|
| DC60598 |
IAG933
Featured
|
IAG933 (IAG-933) is a potent, selective and orally efficacious YAP1/WWTR1(TAZ)-panTEAD protein-protein interaction inhibitor (YAP/TAZ-TEADs PPI), inhibits TEAD-driven transcriptional activity and displays anti-cancer effects. |
|
| DC65702 |
DFHBI-1T
Featured
|
DFHBI-1T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=472 nm/507 nm). DFHBI-1T binds to RNA aptamers (Spinach, Spinach2, iSpinach, and Broccoli) and causes specific fluorescence and lower background fluorescence. DFHBI-1T is used to image RNA in live cells. |
|
| DC65703 |
DFAME
Featured
|
DFAME is a red fluorophore (Ex=508 nm, Em=641 nm). Beetroot and Corn are dimeric fluorogenic RNA aptamers that can bind to DFAME to form Beetroot-DFAME (Kd=460nM) and Corn-DFAME (Kd= 3600nM). Beetroot-DFAME (Kd=460nM) and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research. |
|
| DC65701 |
L-369
Featured
|
L-369 (Lipid 369,L369) is novel class of ionizable lipid for siRNA delivery with improved in vivo elimination profile with excellent translation across species,including NHP, wide safety margin. |
|
| DC65704 |
Mazdutide
Featured
|
Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a glucagon-like peptide-1 (GLP-1R)/glucagon receptor GCGR co-agonist. Mazdutide has safety and tolerability, and it can be used for research in obesity and type 2 diabetes (T2D). |
|
| DC65705 |
Cagrilintide
Featured
|
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity. |
|
| DC60510 |
Iso-A11B5C1
Featured
|
Iso-A11B5C1 is an ionizable lipid. The iso-A11B5C1 LNP demonstrates a high level of muscle-specific mRNA delivery efficiency. exhibiting transfection efficiency comparable to the commercially available lipid SM-102, while considerably reducing inadvertent mRNA expression in main organs such as the liver and spleen.Additionally, study results show that intramuscular administration of mRNA formulated with iso-A11B5C1 LNP caused potent cellular immune responses, even with limited expression observed in lymph nodes. |
|
| DC60511 |
RLY-2608
Featured
|
RLY-2608 is an oral allosteric pan-mutant isoform-selective PI3K伪 inhibitor that was discovered using MD modeling and cryo-EM to identify allosteric networks and opportunities for small molecules, followed by DEL screening.
|
|
| DC60512 |
LY3522348
Featured
|
LY3522348 is a highly selective, oral dual inhibitor of human ketohexokinase isoforms C and A (hKHK-C, hKHK-A). LY3522348 displayed a robust pharmacodynamic response in a mouse model of fructose metabolism and was advanced into clinical trials.
|
|
| DC60513 |
Pelcitoclax
Featured
|
Pelcitoclax, also known as APG 1252 and BM1251, is a potent and selective Bcl-2/Bcl-XL inhibitor. APG-1252 A Bcl-2 homology (BH)-3 mimetic and selective inhibitor of the anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and Bcl-XL, with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2/Bcl-XL inhibitor APG-1252 specifically binds to and inhibits the activity of the pro-survival proteins Bcl-2 and Bcl-XL. This restores apoptotic processes and inhibits cell proliferation in Bcl-2/Bcl-XL-dependent tumor cells.
|
|
| DC60514 |
AM-2-19 (SF001)
Featured
|
AM-2-19 (SF001) is an ergosterol-extracting polyene antifungal that is discovered through modifications to the amphotericin B toxin by chemists. |
|
| DC60515 |
INX-315
Featured
|
INX-315 is a novel and potent CDK2 inhibitor with IC50 of 2.3 nM and shows high selectivity over other CDK family members (374 nM against CDK1/cyclin and 950 nM against CDK9/cyclin,respectively). INX-315 promotes retinoblastoma protein hypo-phosphorylation and therapy-induced senescence (TIS) in CCNE1-amplified tumors, overcomes breast cancer resistance to CDK4/6i and delays the onset of CDK4/6i resistance in breast cancer. |
|
| DC60516 |
TRIM-473
Featured
|
TRIM-473 is a novel ligand for the PRY-SPRY domain of the E3 RING ligase TRIM58 with EC50 of 5.3 μM. |
|
| DC60517 |
Compoud 18 (AEP inhibitor)
Featured
|
Compoud 18 (AEP inhibitor) is first orthosteric, selective, orally bioavailable, and brain penetrant inhibitor with IC50 of 7.8 nM against asparagine endopeptidase (AEP) with an irreversible binding mode. |
.png)
|
| DC60518 |
ACBI3
Featured
|
ACBI3 is a selective, potent and in vivo active pan-KRAS PROTAC degrader, potently degrades 13 out of 17 of the most prevalent oncogenic KRAS alleles (DC50=3.9 nM in GP2d cells). |
|
| DC60519 |
ABBV-467
Featured
|
ABBV-467 is a selective MCL-1 inhibitor. In vivo, intermittent dosing of ABBV-467 as monotherapy or in combination with venetoclax inhibits the growth of xenografts from human hematologic cancers.
|
|
