| DC65600 |
42-(2-Tetrazolyl)rapamycin
Featured
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42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor. |
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| DC65601 |
Hoechst 33342
Featured
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Hoechst 33342 is a DNA minor groove binder used fluorochrome for visualizing cellular DNA. |
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| DC65602 |
BMS-309403 sodium
Featured
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BMS-309403 sodium is a potent, orally active, and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor, with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 sodium interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 sodium improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. |
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| DC65603 |
Mepazine
Featured
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Mepazine (Pecazine) is a potent and selective MALT1 inhibitor. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 and 0.42 μM, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis. |
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| DC65604 |
L-Buthionine (S,R)-sulfoximine
Featured
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L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively. |
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| DC60491 |
C11-MRTX
Featured
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C11-MRTX is a lipid-conjugated MRTX849 analogue with a 11-carbon tail. C11-MRTX is a nonaggregating potent cellular inhibitor of K-Ras(G12C). |
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| DC65591 |
Pim-1 kinase inhibitor 4
Featured
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Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor. |
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| DC65592 |
AChE-IN-30
Featured
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AChE-IN-30 is an AChE inhibitor. |
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| DC60777 |
EN450
Featured
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EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. |
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| DC65594 |
Anticancer agent 129
Featured
|
Anticancer agent 129 (Compound 3a), a quinoline derivative, predicting to has anti-cancer activity. |
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| DC65605 |
WAY-299359
Featured
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WAY-299359 is a FLT3 inhibitor |
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| DC65606 |
WAY-304800-A
Featured
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WAY-304800-A is a Casein kinase 1δ inhibitor. |
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| DC65607 |
WAY-311474
Featured
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WAY-311474 altering the lifespan of eukaryotic organisms. |
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| DC65608 |
WAY-625135
Featured
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WAY-625135 is a Casein kinase 1δ inhibitor. |
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| DC65609 |
WAY-646458
Featured
|
WAY-646458 is a Casein kinase 1d inhibitor. |
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| DC65610 |
WAY-270250
Featured
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WAY-270250 is a IGF-1R/SRC inhibitor. |
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| DC65611 |
WAY-299562
Featured
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WAY-299562 is a modulator of the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP). |
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| DC65612 |
Lenalidomide-acetylene-Br
Featured
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Lenalidomide-acetylene-Br is a PROTAC Linker that makes up HJM-561. |
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| DC65613 |
LZWL02003
Featured
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LZWL02003 is a neuroprotective agent and derivative of N-salicyloyl tryptamine. LZWL02003 upregulated the expression of Bcl-2 and downregulated the expression of Bax, thus maintaining the homeostasis of Bcl-2/Bax proteins and preventing apoptosis. LZWL02003 also reduced oxidative stress by reducing malondialdehyde and reactive oxygen species levels, increasing the superoxide dismutase activity, and resolving mitochondrial malfunction. LZWL02003 can lower interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6 levels, which in turn suppress neuroinflammation. LZWL02003 suppressed the phosphorylation activation of NF-κB pathway-related proteins and decreased the nuclear translocation of NF-κB p65 subunits. LZWL02003 is a neuroprotective agent with pleiotropic effects and may be a candidate for treating cerebral I/R injury. |
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| DC65614 |
AJ2-30
Featured
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AJ2-30 is a SLCl5A4 inhibitor. |
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| DC65615 |
AJ2-71
Featured
|
AJ2-71 is a SLCl5A4 inhibitor. |
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| DC65616 |
JC-229
Featured
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JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei, the causative parasite of African trypanosomiasis. JC-229 is highly toxic to T. brucei cells, while mildly toxic to human cells. JC-229 treatment mimics the effects of TbRPA1 depletion, including DNA replication inhibition and DNA damage accumulation. JC-229 inhibits the activity of TbRPA1, but not the human ortholog. |
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| DC65617 |
TH-Z93
Featured
|
TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM). |
|
| DC60493 |
BEBT-809
Featured
|
BEBT-809 is a GPR75 antagonist for rat CYP4F2 and CYP4A11 with IC50 of and 15.76 nM and 33.16 nM, respectively. |
|
| DC60495 |
9322-O16B
Featured
|
9322-O16B is a lipidoid for the efficient delivery of antiCD19 mRNA CAR to murine primary macrophages. LNP 9322-O16B is more efficient than delivery with lipofectamine 2000 (LPF2K) or MC3. |
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| DC65618 |
DSPE-NHS
Featured
|
DSPE-NHS is a bioconjugation phospholipid molecule with two hydrophobic lipid tails. DSPE-NHS is a self-assembling reagent which forms lipid bilayer in aqueous solution. DSPE-NHS can be used to prepare liposomes as drug nanocarrier. |
|
| DC65629 |
Deslorelin
Featured
|
Deslorelin is a GnRH agonist. Deslorelin implants can be used as an alternative to dopamine agonists to induce fertil eoestrus in the bitch in anoestrus. The deslorelin implant can be used successfully in the queen for oestrus inhibition. Deslorelin acetate did not significantly affect the spontaneous contraction amplitude but caused a decrease in the frequency in the dorsal and ventral parts of the bladder.
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|
| DC65630 |
Melanotan II
Featured
|
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning. |
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| DC65631 |
Teriparatide acetate
Featured
|
Teriparatide is a PHT agonist, with an IC50 of 2 nM in HEK293 cells. Sequence: Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe. |
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| DC65632 |
Tetracosactide acetate
Featured
|
Tetracosactide (INN) is an analogue of adrenocorticotrophic hormone (ACTH), with the biological activity of stimulating production of corticosteroids in the adrenal cortex. Sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro. |
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