Cat. No. | Product name | CAS No. |
DC60171 |
ML353 (VU0478006)
Featured
ML353 (VU0478006) is a ovel Silent Allosteric Modulator (SAM) of the Metabotropic Glutamate Receptor 5. |
|
DC60172 | SY292470 Featured | 1360900-71-5 |
DC60173 |
BR-103354
Featured
BR103354 is a novel fibroblast activation protein (FAP) inhibitor with anti-diabetic and anti-steatotic effects. |
2505339-87-5 |
DC60174 |
CAY10526
Featured
CAY10526 is a selective inhibitor of mPGES-1. It also acts as an inhibitor of the NF-κB signaling pathway. |
938069-71-7 |
DC60175 | VK-28 Featured | 312611-92-0 |
DC58000 |
4'-fluorouridine (4'-FlU, EIDD-2749)
Featured
4'-fluorouridine (4'-FlU, EIDD-2749) is a ribonucleoside analog that inhibits respiratory syncytial virus (RSV), related RNA viruses, and SARS-CoV-2 with high selectivity index (EC50/CC50 of ≥1877) in cells and human airway epithelia organoids. 4'-FlU induces a delayed stalling of RSV and SARS-CoV-2 RdRP (RNA-dependent RNA polymerase). |
1613589-24-4 |
DC60176 |
M1001
Featured
M1001 is a novel allosteric agonist of hypoxia-inducible factor-2α subunit (hif-2α), significantly displacing pocket residue y281 |
874590-32-6 |
DC60177 |
Heparan N-sulfate
Featured
Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix. |
9050-30-0 |
DC60178 | Abatacept Featured | 332348-12-6 |
DC60179 |
HM43239
Featured
HM43239 is an orally active small molecule inhibitor of FLT3 that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. HM43239 also demonstrated inhibition of SYK, JAK1/2 and TAK1, known to be involved in tumor cell proliferation and/or differentiation HM43239 monotherapy induced dose-dependent regression of tumor growth in FLT3 wild-type and FLT3 mutated leukemia cancer cell line. |
2294874-49-8 |
DC60180 |
BUN79398
Featured
BUN79398, also known as MRGPRX1 agonist 1, is a potent MRGPRX1 agonist (Mas-related G-protein-coupled receptor X1) (EC50 of 50 nM). BUN79398 is not only devoid of positively charged amidinium group but also with superior selectivity over opioid receptors. |
2377379-39-8 |
DC60181 |
dCBP-1
Featured
dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and can abolish the enhancer that drives MYC oncogene expression. As an efficient degrader of this unique class of acetyltransferases, dCBP-1 is a useful tool alongside domain inhibitors for dissecting the mechanism by which these factors coordinate enhancer activity in normal and diseased cells. |
2484739-25-3 |
DC58005 |
Z-FF-FMK
Featured
Z-FF-FMK is a cell-permeant and irreversible inhibitor of cathepsin B and cathepsin L. |
105608-85-3 |
DC58006 |
Z-ASTD-FMK
Featured
Z-ASTD-FMK is a cell-permeant and irreversible inhibitor of endothelial monocyte-activated polypeptide II (EMAP II). |
|
DC58007 |
GSK3685032
Featured
GSK-3685032(GSK 3685032) is a first-in-class, potent, non-nucleoside, reversible, selective inhibitor of DNMT1 with IC50 of 0.036 μM. GSK3685032 induces robust loss of DNA methylation, transcriptional activation and cancer cell growth inhibition in vitro. |
2170137-61-6 |
DC58011 |
SKA-31
Featured
SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine) is a potent activator of potassium channel with EC50 of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. |
40172-65-4 |
DC60182 |
Y 39983HCl
Featured
Y-39983, also known as Y-33075, is a potent and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK. Y-39983 attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Y-39983 downregulates RhoA/Rho-associated kinase expression during its promotion of axonal regeneration. Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. |
471843-75-1 |
DC60183 |
GR-103545 fumarate
Featured
GR-103545 is a reference and non-radio labeled agent. The radio-labeled 11C-GR103545 is a promising PET radiotracer for imaging the κ-OR. |
126766-43-6 |
DC58030 |
R-Avanafil
Featured
Avanafil Impurity 8 |
1638497-26-3 |
DC58033 |
Nox inhibitor 1
Featured
Novel Nox inhibitor,N2-(3,4-Dimethylphenyl)-6-((4-(p-tolyl)piperazin-1- yl)methyl)-1,3,5-triazine-2,4-diamine |
|
DC47320 |
FRM-024
Featured
FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease. |
2085780-87-4 |
DC47321 |
Endovion (NS 3728)
Featured
Endovion (NS 3728, SCO-101) is an potent anion channel inhibitor that blocks the Volume Regulated Anion Channels (VRAC). |
265646-85-3 |