Cat. No. | Product name | CAS No. |
DC60439 | XC-DAPOL-CPBA Featured | 191231-97-7 |
DC60440 | 2,3-Dimethyl-1,3,8-triazaspiro[4.5]dec-1-en-4-one hydrochloride Featured | 1774899-05-6 |
DC65001 |
4A3-Cit
Featured
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs). To investigate the role of unsaturated lipid tails in iLNPs, the nucleophilic amines were added to ester-based linkers, followed by Michael’s addition to the thiols to construct a library of 91 amino ionizable lipids. Such ionizable lipids were composed of an ionizable tertiary amine core, an ester-based degradable linker, and an alkylthiol tail periphery. Through in vitro and in vivo screening, the iLNPs with 4A3 core and citronellolbased (Cit) periphery can significantly increase endosome escape and delivery efficiency of mRNA, leading to 18-fold increase in protein expression compared with iLNPs without Cit periphery. Furthermore, the delivery efficiency of mRNA may be associated with the location/configuration of the unsaturated bond(s) in lipids. Although lipids with Cit periphery showed excellent membrane fusion ability to facilitate endosome escape, the fusion mechanism needs to be further clarified. |
2768211-13-6 |
DC65004 |
G0-C14
Featured
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for drug and vaccine delivery[1][2]. |
1510653-27-6 |
DC65005 |
Diuron
Featured
Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male and female mice by 73 and 27%, respectively. |
330-54-1 |
DC65006 | Metasilicic acid Featured | 63231-67-4 |
DC65007 | A2 Featured | 131816-87-0 |
DC65008 | tributylammonium pyrophosphate Featured | 5975-18-8 |
DC65010 |
m-PEG11-alcohol
Featured
m-PEG11-alcohol is a PEG derivative containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. |
9004-74-4 |
DC65011 |
m-PEG3-CH2COOH
Featured
m-PEG3-CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs. |
16024-60-5 |
DC65012 |
m-PEG4-CH2COOH
Featured
m-PEG4-CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs. |
16024-66-1 |
DC65013 |
m-PEG6-CH2COOH
Featured
m-PEG6-O-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
75427-75-7 |
DC65014 |
m-PEG8-CH2COOH
Featured
m-PEG8-CH2COOH is a PEG--based PROTAC linker can be used in the synthesis of PROTACs. |
102013-72-9 |
DC65015 |
m-PEG10-CH2COOH
Featured
m-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
908258-58-2 |
DC65016 |
AGPS-IN-2i
Featured
AGPS-IN-2i is a novel inhibitor of alkylglyceronephosphate synthase (agps), specifically impairing epithelial to mesenchymal transition (emt) by modulating e-cadherin, snail and mmp2 expression levels. |
2316782-88-2 |
DC65017 |
β-Glucuronidase-IN-1
Featured
β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC50 and a Ki of 283 nM and 164 nM, respectively. |
484006-66-8 |
DC65018 | 2-Formyl-3-hydroxybenzoic acid Featured | 1243461-12-2 |
DC65019 |
Isolithocholic acid (β-Lithocholic acid)
Featured
Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate. |
1534-35-6 |
DC65020 | (S)-2-fluoropropionic acid Featured | 57965-29-4 |
DC65021 |
H2-Gamendazole
Featured
H2-Gamendazole is a derivative of Lonidamine that reduces cyst formation in polycystic kidney disease and is used in autosomal dominant polycystic kidney disease research. |
877768-84-8 |
DC65022 | 1,2,5-Oxadithiolane, 2,2,5,5-tetraoxide Featured | 4378-87-4 |
DC65023 |
ACE-083
Featured
ACE083 is a Locally acting muscle-promoting agent |
81080-10-6 |