Cat. No. | Product name | CAS No. |
DC7042 |
GSK-126
Featured
GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase with Ki value of 0.5 nM. |
1346574-57-9 |
DC7422 |
GSK1292263
Featured
GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes. |
1032823-75-8 |
DC8766 |
GSK1324726A (I-BET726)
Featured
GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), and BRD4 (IC50= 22 nM). |
1300031-52-0 |
DC8577 |
FFA4 (GPR120) agonist GSK137647A
Featured
GSK-137647 is a potent and selective FFA4 (GPR120) agonist (pEC50 values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. |
349085-82-1 |
DC9705 |
GSK163090
Featured
GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3, respectively. |
844903-58-8 |
DC10124 |
GSK180736A
Featured
GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM. |
817194-38-0 |
DC10102 |
GSK189254A
Featured
GSK189254A (GSK189254) is a novel, potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively. |
720690-73-3 |
DC9714 |
SCD inhibitor GSK1940029
Featured
GSK1940029 is a stearoyl CoA desaturase 1 inhibitor. |
1150701-66-8 |
DC20282 |
GSK199
Featured
GSK199 is a reversible inhibitor of PAD4 (IC50 = 200 nM) that binds to the low-calcium form of the enzyme and is selective for PAD4 over PAD1-3. |
1549811-53-1 |
DC11415 |
GSK2033
Featured
GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively. |
1221277-90-2 |
DC7141 |
Omipalisib
Featured
GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively. |
1086062-66-9 |
DC10865 |
GSK2193874
Featured
GSK2193874 is an orally active, potent, and selective TRPV4 antagonist with IC50 of 2 nM and 40 nM for rTRPV4 and hTRPV4. |
1336960-13-4 |
DC10912 |
GSK-2200150A
Featured
GSK2200150A is an antimycobacterial agent against Mycobacterium tuberculosis and Mycobacterium bovis BCG. |
1443138-53-1 |
DC8331 |
GSK2256098
Featured
GSK2256098 is small molecule FAK kinase inhibitor. |
1224887-10-8 |
DC7650 |
GSK2334470
Featured
GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases. |
1227911-45-6 |
DC8520 |
GSK-25
Featured
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
874119-56-9 |
DC8767 |
GSK256066
Featured
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. |
801312-28-7 |
DC7852 |
LRRK2 inhibitor GSK2578215A
Featured
GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant. |
1285515-21-0 |
DC7142 |
GSK2606414
Featured
GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM. |
1337531-36-8 |
DC6315 |
GSK2636771
Featured
GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitive to PTEN null cell lines. Phase 1/2a. |
1372540-25-4 |
DC12049 |
GSK2643943A
Featured
GSK2643943A is a potent USP20 inhibitor with IC50 = 160 nM. |
|
DC5029 |
PERK inhibitor GSK2656157
Featured
GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC50 of 0.9 nM. It is highly selective for PERK with IC50 values >100 nM against a panel of 300 kinases. |
1337532-29-2 |