| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11757 | PB 28 | A potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively. |
|
| DC11629 | NK1-IN-9 | A potent, orally active, dual NK1 receptor antagonist (IC50=0.5 nM) and SERT inhibitor (IC50=5.2 nM). |
|
| DC11697 | AM-1638 | A potent, orally bioavailable, full agonist of GPR40/FFA1 with EC50 of 0.16 uM. |
|
| DC11979 | SB 332235 | A potent, selective and competitive CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with pKi of 8.92. |
|
| DC11755 | L-732138 Featured | A potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM. |
|
| DC11514 | Atogepant | A potent, selective and orally available CGRP receptor antagonist for the prevention of migraine. Migraine. |
|
| DC11519 | Ceclazepide | A potent, selective cholecystokinin receptor CCK2 antagonist for treatment of gastroesophageal reflux disease (GERD).. |
|
| DC12015 | SKF 83566 hydrobromide | A potent, selective dopamine D1 receptor antagonist with Ki of 0.56 nM. |
|
| DC11973 | A-412997 | A potent, selective dopamine D4 receptor agonist with Ki of 12.1 and 7.9 nM for rat and human D4 receptors, respectively. |
|
| DC11700 | Chalcone 4 hydrate | A potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM. |
|
| DC11560 | SPM-242 | A potent, selective S1P3 antagonist with Ki of 0.25 nM. |
|
| DC11561 | SPM-242 racemate | A potent, selective S1P3 antagonist with Ki of 0.25 nM. |
|
| DC11745 | BMS-22 | A potent, selective, allosteric CCR2 antagonist with binding IC50 of 5.1 nM. |
|
| DC11744 | CCR2-RA-[R] | A potent, selective, allosteric CCR2 antagonist with IC50 of 103 nM.. |
|
| DC11895 | Foliglurax hydrochloride | A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
|
| DC11894 | Foliglurax | A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
|
| DC11666 | BMS-470539 | A potent, selective, full agonist of human and murine MC1R with EC50 of 16.8 and 11.6 nM, respectively. |
|
| DC11746 | JNJ-27141491 | A potent, selective, noncompetitive, orally active CCR2 antagonist with IC50 of 172 nM. |
|
| DC11756 | SR 140333 | A potent, selective, non-peptide NK1 receptor antagonist with Ki of 0.74 nM, IC50 of 1.6 nM. |
|
| DC11667 | PF-592379 | A potent, selective, orally active agonist of dopamine D3 receptor with EC50 of 21 nM. |
|
| DC11683 | LY2881835 | A potent, selective, orally available GPR40 agonist with EC50 of 8 nM. |
|
| DC11682 | LY2922083 | A potent, selective, orally available GPR40 agonist with EC50 of 9 nM. |
|
| DC11680 | LY3104607 | A potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM. |
|
| DC11623 | GPR120 agonist 4x | A potent, selective, orally bioavailable GPR120 agonist with EC50 of 42 nM in calcium flux assays. |
|
| DC11748 | LY2033298 Featured | LY2033298 is a robust allosteric potentiator that is highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 enhances inhibition by oxotremorine of light-induced phase shifts in hamster circadian activity rhythms. |
|
| DC11978 | SB 265610 Featured | SB-265610 is a selective, competitive, nonpeptide and allosteric CXCR2 antagonist. |
|
| DC11983 | CX797 | A potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM. |
|
| DC11977 | SX-517 | A potent, specific, noncompetitive dual CXCR1 and CXCR2 antagonist with IC50 of 38 nM (vs. CXCL1) and 36 nM (vs. CXCL8), respectively. |
|
| DC11972 | PNU 96415E | A potential antipsychotic agent that binds selectively to D4 and 5-HT2A receptors with Ki of 3.0 and 5.8 nM, respectively. |
|
| DC11545 | IPAG Featured | IPAG is a prototypic selective inhibitor of sigma1 receptor that engages the unfolded protein response and induces autophagy in cancer cells. |
|
