| DC8765 |
AM251
Featured
|
AM251 is a potent CB1 receptor antagonist (IC50 = 8 nM, Ki = 7.49 nM) that displays 306-fold selectivity over CB2 receptors; also potent GPR55 agonist (EC50 = 39 nM). |
|
| DC8886 |
Iodopravadoline(AM-630)
Featured
|
AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 µM and 31.2 nM, respectively. |
|
| DC11552 |
AM-6538 |
AM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM.. |
|
| DC11221 |
AM9405 |
AM9405 (AM-9405) is novel potent, peripherally active cannabinoid type 1 (CB1) and 5-HT3 receptor agonist, inhibits the EFS-induced twitch contraction of the ileum and the colon with IC50 of 0.076 and 45.71 nM, respectively. |
|
| DC8623 |
AM966
Featured
|
AM966 is a high affinity, selective, oral LPA1 (lysophosphatidic acid receptor, IC50=17 nM) antagonist, with selectivity for this receptor over the other LPA receptors. |
|
| DC5056 |
AMD3465
Featured
|
AMD3465 is a Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). |
|
| DC7867 |
AMG-837
Featured
|
AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
|
| DC6310 |
AMG 853(AMG853;Vidupiprant) |
AMG 853 is novel a CRTH2 and DP Dual Antagonist. |
|
| DC5083 |
Cinacalcet (AMG-073) HCl
Featured
|
AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism. |
|
| DC11747 |
Iperoxo |
Iperoxo is a superagonist of the muscarinic acetylcholine receptors and an OxotremorineM analog. |
|
| DC7357 |
Anamorelin
Featured
|
Anamorelin(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia. |
|
| DC11428 |
Olorinab |
APD-371 (APD371, Olorinab) is a potent, selective and orally available CB2 agonist with EC50 of 6.2 nM; displays no activity against CB1 receptors (EC50>10 uM); exhibits activity in rat model of osteoarthritis pain. |
|
| DC11513 |
Aprocitentan (ACT-132577)
Featured
|
Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting. |
|
| DC10731 |
Arecaidine but-2-ynyl ester tosylate |
Arecaidine but-2-ynyl ester tosylate is a potent muscarinic agonist that shows 4.6-fold that is selectivity for mAChR M2 in the atrium versus those in the ileum. |
|
| DC9147 |
Aripiprazole |
Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. |
|
| DC11174 |
ASP7657
Featured
|
ASP7657 (ASP-7657) is a potent, selective, orally active prostaglandin EP4 receptor antagonist with Ki values of 6.02 nM and 2.21 nM for rat and human EP4 receptors, resepctively. |
|
| DC7364 |
AT-56
Featured
|
AT-56 is a selective, competitive, and highly bioavailable inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) with a Ki value of 75 µM. |
|
| DC9020 |
Atenolol |
Atenolol is a selective β1 receptor antagonist. |
|
| DC9878 |
ATI-2341 |
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. |
|
| DC8998 |
Atipamezole HCl |
Atipamezole Hcl(MPV1248 Hcl) is an alpha-adrenoceptor antagonist with high affinity and selectivity for the alpha 2-receptor. |
|
| DC8925 |
Atipamezole
Featured
|
Atipamezole(MPV1248) is an alpha-adrenoceptor antagonist with high affinity and selectivity for the alpha 2-receptor. |
|
| DC10018 |
Atrasentan hydrochloride
Featured
|
Atrasentan Hcl(A-147627) is an endothelin antagonist receptor (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer. |
|
| DC11399 |
AVN-492
Featured
|
AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM). |
|
| DC9436 |
Avosentan |
Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.
|
|
| DC11147 |
AZ084 |
AZ084 (AZ-084) is a potent, selective, allosteric, orally available CCR8 antagonist with Ki of 0.9 nM. |
|
| DC11975 |
AZ 10397767 |
AZ10397767 is a potent, selective CXCR2 inhibitor that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.0. |
|
| DC10879 |
AZ3451
Featured
|
AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2) |
|
| DC11742 |
AZ-8838 |
AZ-8838 (AZ8838) is a potent, and selective PAR2 antagonist with Kd of 125 nM. |
|
| DC8713 |
Azaperone |
Azaperone acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug
with sedative and antiemetic effects, which is used mainly as a tranquilizer in |
|
| DCAPI1427 |
Azasetron HCL |
Azasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic. |
|
