Cat. No. | Product name | CAS No. |
DC47258 |
Carbetocin acetate
Carbetocin acetate, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin acetate has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin acetate has the potential for postpartum hemorrhage research. Carbetocin acetate can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS. |
1631754-28-3 |
DC47266 |
SKF83822 hydrobromide
SKF83822 hydrobromide is a potent dopamine D1 receptor agonist. SKF83822 hydrobromide activates Gs/olf/adenylyl cyclase (AC)-coupled D1 receptors, but not phospholipase C (PLC)-coupled D1-like receptors. |
74115-10-9 |
DC47270 |
(S)-Amisulpride
Featured
(S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a KI of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects. |
71675-92-8 |
DC47359 |
SCH79797
SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes. |
245520-69-8 |
DC47373 |
CAY10580
CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM). |
64054-40-6 |
DC47374 |
Aligeron
Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties. |
70713-45-0 |
DC47541 |
SC13
SC13 is a novel mitragynine analog with low-efficacy Mu opioid receptor agonism that displays antinociception with attenuated adverse effects. |
|
DC47552 |
VGD071
VGD071, a sortilin-targeting compound, is a promising candidate for future studies using mouse breast cancer models. |
|
DC47572 |
PHCCC(4Me)
PHCCC(4Me) (THCCC), a PHCCC analog, is a dual mGluR2 (IC50 of 1.5 μM) negative allosteric modulator and mGluR3 (EC50 of 8.9 μM) positive allosteric modulator. |
1259532-01-8 |
DC47573 |
α-MSH free acid
α-MSH (free acid) is a MC3R and MC4R agonist with an EC50 of 0.16±0.09 nM and 5.6±6.8 nM, respectively. α-MSH (free acid) activates cAMP generation at MC3R and MC4R. |
10466-28-1 |
DC47578 |
(Rac)-5-Hydroxymethyl Tolterodine
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research. |
200801-70-3 |
DC47579 |
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research. |
250214-40-5 |
DC47580 |
Navafenterol
Navafenterol (AZD-8871) is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC50 is 9.5 for human M3 receptor, and the pEC50 is 9.5 for β2-adrenoceptor. Navafenterol can be used for the research of chronic obstructive pulmonary disease (COPD). Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile. |
1435519-06-4 |
DC47581 |
BMS-986278
Featured
BMS-986278 is a potent lysophosphatidic acid receptor 1 (LPA1) antagonist, with a human LPA1 Kb of 6.9 nM. |
2170126-74-4 |
DC47582 |
S1P2 antagonist 1
S1P2 antagonist 1 is an orally bioavailable S1P2 antagonist against fibrotic diseases. |
2262402-83-3 |
DC47583 |
W146 TFA
W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. |
909725-62-8 |
DC47622 |
Cyclizine
Featured
Cyclizine is a piperazine first-generation antagonist of histamine 1 receptor. |
82-92-8 |
DC47628 |
GPR84 antagonist 1
GPR84 antagonist 1 is a high affinity and highly selective competitive antagonist of human GPR84. |
|
DC47629 |
5-HT7R antagonist 1 free base
5-HT7R antagonist 1 (free base) is a G protein-biased antagonist against 5-HT7R (Ki = 6.5 nM). |
2337008-64-5 |
DC47630 |
5-HT7R antagonist 1
5-HT7R antagonist 1 is a G protein-biased antagonist against 5-HT7R (Ki = 6.5 nM). |
|
DC47635 |
GLP-1R modulator L7-028
GLP-1R modulator L7-028 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 11.01 ± 2.73 μM). |
2648317-95-5 |
DC47636 |
GLP-1R modulator C5
GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM). |
421578-93-0 |